Pycnogenol^® treatment of acute hemorrhoidal episodes

Abstract

We investigated the efficacy of orally and topically applied Pycnogenol for the management of acute hemorrhoidal attacks in a controlled, randomized study with 84 subjects. Within less than 48 h of onset of an acute attack, patients were enrolled and signs and symptoms were scored. This evaluation was repeated after seven days' treatment and again seven days following treatment cessation. The decrease in scores was significantly more pronounced in the Pycnogenol-treated groups than in the control group given placebo (p < 0.05), showing the efficacy of Pycnogenol for relieving signs and symptoms of acute external hemorrhoids. In a group of patients given topical (0.5%) Pycnogenol in addition to oral Pycnogenol the improvement in symptoms set in significantly faster and was more pronounced. The most prominent symptom, hemorrhoidal bleeding, was completely absent in all patients treated with Pycnogenol for seven days and also at the 14 days follow-up. In contrast, bleedings were still observed in the control group during the two weeks follow-up. This study indicates that Pycnogenol, both in oral and in topical form, is effective for controlling this common, disabling health problem. The application of Pycnogenol eases the management of acute hemorrhoidal attacks and help avoid bleedings.

Pycnogenol® bei Erkrankungen des venösen Systems - eine systematische Übersicht

“…In einer placebokontrollierten Doppelblindstudie wurden Patienten spätestens 48 h nach Auftreten einer akuten hämorrhoidalen Episode mit 300 mg Pycnogenol für die ersten 3 Tage und danach für 3 Tage mit 150 mg Pycnogenol behandelt (n = 84) [29]. Die orale Gabe wurde bei einem Teil der Patienten durch die lokale Applikation eines 0,5% Pycnogenol enthaltenden Gels ergänzt.…”

Pycnogenol® in Chronic Venous Insufficiency and Related Venous Disorders

“…The results obtained in this study indicate that Pycnogenol, both in oral and in topical form, is effective for controlling the haemorrhoidal episode. The topical application of Pycnogenol eased the pain of acute haemorrhoidal attacks and helped avoid bleeding (Belcaro et al ., ).…”

Phytochemical and Antioxidant-Related Investigations on Bark of Abies spectabilis (D. Don) Spach. from Nepal

“…Although the bark of coniferous tree species is considered as a waste product in the timber industry, it is rich in secondary metabolites, especially phenol and lignan derivatives [ 1 , 2 , 3 , 4 ]. As an example, a standardised extract from the French maritime pine ( Pinus pinaster ) bark has been patented as Pycnogenol®, which is used extensively in the cosmetics and herbal products industry [ 5 , 6 , 7 , 8 , 9 , 10 ].…”