Pyelonephritis caused by <i>Mannheimia varigena</i> in a Holstein calf

Abstract

A 7-day-old calf died following development of mild respiratory symptoms. Postmortem examination revealed the kidneys were inflamed, and Gram-negative bacteria was detected in the kidneys, supporting the diagnosis of suppurative pyelonephritis. Mannheimia varigena antigen was found in the lesions and the cytoplasm of macrophages and neutrophils in the renal cortex. The Gram-negative bacilli from the kidney were identified as M. varigena by sequencing the 16S rDNA. Although M. varigena is known to cause bovine respiratory disease syndrome, shipping fever, and meningitis, it was unknown that it could also cause suppurative pyelonephritis. Our study provides the first evidence of suppurative pyelonephritis caused by M. varigena in cattle and information that would improve our understanding, diagnosis, and treatment for M. varigena infections.

A Longitudinal Characterization of the Seminal Microbiota and Antibiotic Resistance in Yearling Beef Bulls Subjected to Different Rates of Gain

“…A number of seminal bacterial isolates recovered are known pathogens involved in bovine diseases. These pathogenic isolates include Fusobacterium necrophorum and Trueperella pyogenes , which are principal bacterial species associated with liver abscesses ( 43 ); Histophilus somni (bovine respiratory disease ( 44 )), Mannheimia varigena (bovine respiratory disease and kidney infection in cattle ( 44 , 45 )), Trueperella abortisuis ( 46 ), and Bacillus cereus ( 47 ), which can cause abortion ( 46 ); Fusobacterium gastrosuis (foot rot and lameness) ( 48 ); and A. gandavensis , which has been reported to be associated with reproductive loss ( 49 ) and mastitis ( 50 ) (Table S3). The presence of these pathogenic species among the seminal microbial community begs an important question of whether bovine semen serves as a medium for transferring pathogens to female cattle through mating and, ultimately, to the offspring calves.…”

Characterizing the blood microbiota of omnivorous and frugivorous bats (Chiroptera: Phyllostomidae) in Casanare, eastern Colombia

“…In terms of the ecological features of the communities of bat blood microbiota, the most abundant bacteria genera ( Mycoplasma , Bartonella , Acinetobacter and Mannhemia ) have been detected in blood as well as other histological samples (spleen and heart) ( Correia Dos Santos et al, 2020 ; Corduneanu et al, 2021 ; Descloux et al, 2021 ). In bats, the information is scarce in terms of the functional roles and ecological features of these bacteria, but some species are associated with different zoonotic diseases such as Bartonellosis and Pneumonia ( Mühldorfer, 2013 ; Morris et al, 2019 ; Komatsu et al, 2019 ). The several studies that described these zoonotic species used specific tools (PCR or Sanger sequencing) to determine the presence or absence of these microbes ( Mühldorfer, 2013 ; Morris et al, 2019 ; Komatsu et al, 2019 ).…”

“…In bats, the information is scarce in terms of the functional roles and ecological features of these bacteria, but some species are associated with different zoonotic diseases such as Bartonellosis and Pneumonia ( Mühldorfer, 2013 ; Morris et al, 2019 ; Komatsu et al, 2019 ). The several studies that described these zoonotic species used specific tools (PCR or Sanger sequencing) to determine the presence or absence of these microbes ( Mühldorfer, 2013 ; Morris et al, 2019 ; Komatsu et al, 2019 ). However, these techniques cannot characterize and/or describe the ecology of these bacteria.…”

A longitudinal characterization of the seminal microbiota and antibiotic resistance in yearling beef bulls subjected to different rate of gains using 16S rRNA gene sequencing and culturing

“…These pathogenic isolates include Fusobacterium necrophorum and Trueperella pyogenes which are principal bacterial species associated with liver abscesses [48], Histophilus somni (Bovine respiratory disease [49], Mannheimia varigena (Bovine respiratory disease and kidney infection in cattle [49,50]), Trueperella abortisuis [51] and Bacillus cereus [52] which can cause abortion [51], Fusobacterium gastrosuis (foot rot and lameness [53]) and A. gandavensis which has been reported to be associated with reproductive loss [54] and mastitis [55] (Table S3). The presence of these pathogenic species among the seminal microbial community begs an important question of whether bovine semen serves as a medium for transferring pathogens to female cattle through mating, and ultimately to the offspring calves.…”