2017
DOI: 10.1101/216770
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Pyk2 suppresses contextual fear memory in a kinase-independent manner

Abstract: 17Post-traumatic stress disorder (PTSD) is a psychological illness characterized by 18 recalling a feeling of distress when re-experiencing the original trauma-related 19 cues. This associative fear response plays an important role in some psychiatric 20 disorders and elucidation of the underlying mechanisms is of great importance. 21Here, we constructed Pyk2 null mice and found that these mutant mice showed 22 enhancement in contextual-fear memory, but no changes in auditory-cued and 23 spatial-referenced lea… Show more

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Cited by 1 publication
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“…Consistently, the C-terminal FAT domain of Pyk2 is not required for the blocking effect and the kinase domain alone cannot block cortical neuron migration ( Figure 4—figure supplement 1A and C ). This is consistent with that Pyk2 has important kinase-independent functions in contextual fear memory ( Suo et al, 2017 ). Together, we conclude that both Pyk2 kinase cascade and FERM scaffold are crucial for blocking cortical neuron migration.…”
Section: Resultssupporting
confidence: 91%
“…Consistently, the C-terminal FAT domain of Pyk2 is not required for the blocking effect and the kinase domain alone cannot block cortical neuron migration ( Figure 4—figure supplement 1A and C ). This is consistent with that Pyk2 has important kinase-independent functions in contextual fear memory ( Suo et al, 2017 ). Together, we conclude that both Pyk2 kinase cascade and FERM scaffold are crucial for blocking cortical neuron migration.…”
Section: Resultssupporting
confidence: 91%