Pyloric Campylobacter Serology

Marshall, Barry J.; Mcgechie, D.; Francis, GrahamJ.; Utley, P.

doi:10.1016/s0140-6736(84)90318-0

Cited by 95 publications

(43 citation statements)

References 3 publications

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“…H. pylori infection almost constantly induces a specific systemic immune response which may reflect the antibodies produced at the gastric mucosal level, while only 2% of patients fail to seroconvert (276). This response was used for the diagnosis of this infection immediately following the discovery of H. pylori (236,343). The immune response varies according to the antigens present in the infecting strains and to the host.…”

Section: Detection Of H Pylori Antibodiesmentioning

confidence: 99%

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Helicobacter pyloriDetection and Antimicrobial Susceptibility Testing

2007

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SUMMARY The discovery of Helicobacter pylori in 1982 was the starting point of a revolution concerning the concepts and management of gastroduodenal diseases. It is now well accepted that the most common stomach disease, peptic ulcer disease, is an infectious disease, and all consensus conferences agree that the causative agent, H. pylori, must be treated with antibiotics. Furthermore, the concept emerged that this bacterium could be the trigger of various malignant diseases of the stomach, and it is now a model for chronic bacterial infections causing cancer. Most of the many different techniques involved in diagnosis of H. pylori infection are performed in clinical microbiology laboratories. The aim of this article is to review the current status of these methods and their application, highlighting the important progress which has been made in the past decade. Both invasive and noninvasive techniques will be reviewed.

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Section: Detection Of H Pylori Antibodiesmentioning

confidence: 99%

“…A passive hemagglutination test using an H. pylori sonicate appeared to have a better sensitivity (343). A latex agglutination was also proposed (220,568), but the essential technique used for more than 20 years is the standard ELISA and its derivatives, such as rapid immunoenzymatic assays and immunoblotting.…”

Section: Detection Of H Pylori Antibodiesmentioning

confidence: 99%

Helicobacter pyloriDetection and Antimicrobial Susceptibility Testing

2007

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“…pylori has proved to be a useful tool in the diagnosis of H. pylori infection. Differ ent methods of antibody detection have been developed, including complement fixation tests [57], passive haemagglutination assays [58], enzyme-linked immunosorbent assays (ELISA) [52,59], and immunoblot techniques [60,61]. Detection o f//, pylori by means ofin situ DNA hybridization is a sophisticated method not yet available to most investiga tors [62], Currently, the IgG ELISA is the most common technique.…”

Section: Imon-invasive Techniquesmentioning

confidence: 99%

A Review of Diagnostic Techniques for <i>Helicobacter pylori </i>Infection

Loffeld¹,

Stobberingh²,

Arends

1993

Dig Dis

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The description of Helicobacter pylori and an understanding of its pathogenetic significance has been one of the major breakthroughs in gastroenterology in the past decade. Because of the possible implications, a correct diagnosis of the infection is mandatory. Diagnostic techniques can be divided into invasive and non-invasive methods. The first require upper gastrointestinal endoscopy with a biopsy taken from the stomach. These biopsy specimens can be studied for the presence of H. pylori using several histological staining techniques, or culture. In addition, urease tests are possible. The non-invasive techniques do not require endoscopy. They comprise testing for the presence of antibodies against H. pylori in the patient’s serum, or breath tests with ¹³C- or ¹⁴C-labelled urea. In experienced hands every test has good sensitivity and specificity, and the test to be applied depends on local preference and experience.

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“…Helicobacter pylori is the major etiologic agent for chronic active gastritis and also plays a crucial role in gastric and duodenal ulcer disease, as well as in gastric carcinoma (1). The eradication of H. pylori infection improves histological gastritis, decreases the rate of recurrence of gastric and duodenal ulcer disease, and may prevent the occurrence of gastric carcinoma (2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%