’Pyloric gland-type adenoma' arising in heterotopic gastric mucosa of the duodenum, with dysplastic progression of the gastric type

Kushima, Ryoji; Rüthlein, H. J.; Stolte, Manfred; Bamba, Masamichi; Hattori, Takanori; Borchard, F

doi:10.1007/s004280050425

Cited by 62 publications

(60 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4 Extragastric PGAs have also been associated with pyloric gland metaplasia in the setting of chronic mucosal injury. 3,5,11 PATHOLOGIC FEATURES AND IMMUNOPHENOTYPE Pyloric gland adenomas have a histologic appearance that is similar to nonneoplastic gastric pyloric glands. They are composed of tightly packed tubular glands lined with cuboidal or columnar cells (Figure 1, A).…”

Section: Clinical and Endoscopic Featuresmentioning

confidence: 99%

“…They are most frequently identified in the stomach. Extragastric sites of PGAs include the gallbladder, duodenum, bile duct, and esophagus [1][2][3][4] ; in the pancreas, similar lesions are termed intraductal papillary mucinous neoplasms of the gastric type, pyloric gland variant, and intraductal papillary mucinous neoplasm with pyloric gland features. 5,6 Pyloric gland adenomas should be recognized as neoplasms with risk for transformation into invasive adenocarcinoma.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Gastric Pyloric Gland Adenoma

Pezhouh

Park

2015

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

Pyloric gland adenomas are rare neoplasms of the gastrointestinal tract. Gastric pyloric gland adenomas have been shown to arise in chronically damaged mucosa. The neoplastic glands have gastric pyloric gland differentiation and have a tightly packed organization with occasional cystic dilatation. The individual cells are cuboidal to columnar, with eosinophilic to amphophilic cytoplasm and either no apical mucin cap or a poorly formed apical mucin cap. The nuclei are round to oval, with occasional prominent nucleoli. Immunohistochemically, the neoplastic cells label with markers of gastric pyloric gland differentiation, including MUC6 and MUC5AC. There is limited information regarding the natural history of pyloric gland adenomas, but clinical series have described adenocarcinomas in association with gastric pyloric gland adenomas. The ideal clinical management is adequate sampling of the lesion to investigate for high-grade dysplasia and/or invasive cancer and recommendation to clinical colleagues to investigate the background mucosa for the etiology of chronic gastritis as well as potential additional neoplastic lesions. This review will focus on gastric pyloric gland adenomas.

show abstract

Section: Clinical and Endoscopic Featuresmentioning

confidence: 99%

mentioning

confidence: 99%

Gastric Pyloric Gland Adenoma

Pezhouh

Park

2015

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

show abstract

“…Borchard presented two cases of pyloric gland adenoma with transition to adenocarcinoma at slide seminars in Germany in 1986 and 1987 (unpublished data). Similar adenomas of the gastric type were subsequently described in gastric heterotopia in the duodenum [34], in the pancreatic duct [35], and, in particular, in the gallbladder [36,37]. In 2003, we first reported systematic clinicopathological analyses of pyloric gland adenoma, in English language and Japanese journals [38,39].…”

Section: Gastric-type Adenoma (Pyloric Gland Adenoma)mentioning

confidence: 99%

Gastric-type well-differentiated adenocarcinoma and pyloric gland adenoma of the stomach

et al. 2006

View full text Add to dashboard Cite

found that gastric carcinomas could be broadly divided into gland-forming adenocarcinomas and poorly differentiated carcinomas, which included signet-ring cell carcinomas. The former were found to retain intestinal features, and the latter tended to disclose a diffusely infiltrative growth pattern; Laurén referred to these as intestinal-type and diffuse-type, respectively, reporting that 53% of his samples were intestinal-type, 33% were diffuse-type, and the remaining 14% were unclassifiable [1].In the differentiated adenocarcinomas, intestinal metaplasia was often seen in the stomach, and intestinaltype cancers were thought to arise from the intestinal metaplasia. On the other hand, diffuse-type cancers did not retain intestinal characteristics, and they were considered to arise in the ordinary gastric mucosa, which was not involved in intestinal metaplasia [2,3]. In the middle of the 1980s, Helicobacter pylori was found to cause chronic active gastritis, and it was suggested that H. pylori played an important role in gastric carcinogenesis. In this respect, a hypothesis was that H. pylori caused chronic active gastritis with intestinal metaplasia, resulting in the development of intestinal-type adenocarcinomas [4,5].However, several studies appeared which described well-differentiated adenocarcinomas arising in nonintestinalized gastric mucosa, and there has been a question whether well-differentiated adenocarcinomas of the stomach were exclusively intestinal type. The recent discovery of MUC genes coding core proteins of mucin has identified the phenotypic expression of gastrointestinal neoplasms [6][7][8]. The disease entity of "gastric-type well-differentiated adenocarcinoma" has recently been accepted, especially in Japan and Europe. This entity has often been a clinicopathological subject of discussion, especially in Japanese journals, because its biological behavior is possibly highly malignant, in spite of the difficulty of making endoscopic and histopathological diagnoses [9,10]. AbstractSince 1985, when gastric-type well-differentiated adenocarcinomas were demonstrated in hyperplastic polyps of the stomach, we have studied phenotypic expression in gastrointestinal epithelial lesions. The recent discovery of MUC genes coding core proteins of mucin has improved research on the phenotypic expression of gastrointestinal neoplasms. The disease entity of gastric-type well-differentiated adenocarcinoma has recently been accepted, especially in Japan and Europe. This entity has often become a clinicopathological subject of discussion, because its biological behavior is possibly highly malignant, in spite of the difficulty in making endoscopic and histopathological diagnoses. Even under these circumstances, the term "gastric adenoma" usually means flat adenoma of the intestinal type. Gastric-type adenomas have been regarded as exceptional until recently. Although gastric-type adenomas could theoretically be classified into foveolar type and pyloric-gland type, foveolar-type adenoma is, in practice, difficult t...

show abstract

“…Borchard presented two cases of pyloric gland adenoma with transition to adenocarcinoma during two slide seminars in 1986 and 1987 (F. Borchard, personal communication). Similar adenomas of the gastric type were subsequently described in gastric heterotopia in the duodenum [14], in the pancreatic duct [1] and, in particular, in the gallbladder [7,11,17]. We recently reported a clinico-pathological analysis of 90 cases of pyloric gland adenoma [24].…”

Section: Introductionmentioning

confidence: 94%

Pyloric gland adenoma arising in Barrett’s esophagus with mucin immunohistochemical and molecular cytogenetic evaluation

et al. 2005

View full text Add to dashboard Cite

Pyloric gland adenoma is a recently described and very rare entity. The occurrence of adenoma is very unusual in Barrett's epithelium of the esophagus. We report a case of esophageal polyp showing the features of pyloric gland adenoma, which was surrounded by so-called specialized columnar epithelium. Immunohistochemically, most tumor glands were strongly positive for MUC6, except in the superficial layer. MUC5AC was positive in almost all tumor cells, but MUC2 and CD10 were negative in the tumor. MIB-1-positive proliferating cells were distributed throughout the tumor. Microdissection and comparative genomic hybridization analyses revealed losses on 2p24-25.2, 2q14.1-ter, 5q31.3-32, 6q23-24, 8q23-24.2, 11q22.3-24 and 18q21.1-22. This is the first case of pyloric gland adenoma found to arise in Barrett's epithelium of the esophagus, showing its unstable and precancerous nature.

show abstract

’Pyloric gland-type adenoma' arising in heterotopic gastric mucosa of the duodenum, with dysplastic progression of the gastric type

Cited by 62 publications

References 18 publications

Gastric Pyloric Gland Adenoma

Gastric Pyloric Gland Adenoma

Gastric-type well-differentiated adenocarcinoma and pyloric gland adenoma of the stomach

Pyloric gland adenoma arising in Barrett’s esophagus with mucin immunohistochemical and molecular cytogenetic evaluation

Contact Info

Product

Resources

About