Pyoderma gangrenosum and necrotizing fasciitis‐like opportunistic invasive cutaneous fungal infection

Aytekin, Sema; Güder, Hüsna; Göktay, Fatıh; Yaşar, Şirin; Aker, Fügen; Aksaray, Sebahat

doi:10.1111/ijd.13296

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…Sometimes it mimics necrotizing fasciitis [22]. Very rarely PG and necrotizing fasciitis-like opportunistic fungal infections are observed within skin biopsy specimens of the same host [23]. Our patient's wound presumed to be sterile but the patient was under pressure of antibiotics.…”

Section: Discussionmentioning

confidence: 96%

Chronic Lymphocytic Leukemia and Autoimmune Cytopenias: Pathogenesis, Diagnosis and Treatment

Yilmaz¹,

Kiper²,

Vural³

2017

SOJI

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Section: Discussionmentioning

confidence: 96%

Chronic Lymphocytic Leukemia and Autoimmune Cytopenias: Pathogenesis, Diagnosis and Treatment

Yilmaz¹,

Kiper²,

Vural³

2017

SOJI

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Leg Ulcers: Expanding the Differential

Keller

2018

Curr Derm Rep

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Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections

Neoh,

Chen,

Lanternier

et al. 2024

Clin Microbiol Rev

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SUMMARY Although Scedosporium species and Lomentospora prolificans are uncommon causes of invasive fungal diseases (IFDs), these infections are associated with high mortality and are costly to treat with a limited armamentarium of antifungal drugs. In light of recent advances, including in the area of new antifungals, the present review provides a timely and updated overview of these IFDs, with a focus on the taxonomy, clinical epidemiology, pathogenesis and host immune response, disease manifestations, diagnosis, antifungal susceptibility, and treatment. An expansion of hosts at risk for these difficult-to-treat infections has emerged over the last two decades given the increased use of, and broader population treated with, immunomodulatory and targeted molecular agents as well as wider adoption of antifungal prophylaxis. Clinical presentations differ not only between genera but also across the different Scedosporium species. L. prolificans is intrinsically resistant to most currently available antifungal agents, and the prognosis of immunocompromised patients with lomentosporiosis is poor. Development of, and improved access to, diagnostic modalities for early detection of these rare mold infections is paramount for timely targeted antifungal therapy and surgery if indicated. New antifungal agents (e.g., olorofim, fosmanogepix) with novel mechanisms of action and less cross-resistance to existing classes, availability of formulations for oral administration, and fewer drug-drug interactions are now in late-stage clinical trials, and soon, could extend options to treat scedosporiosis/lomentosporiosis. Much work remains to increase our understanding of these infections, especially in the pediatric setting. Knowledge gaps for future research are highlighted in the review.

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Pyoderma gangrenosum and necrotizing fasciitis‐like opportunistic invasive cutaneous fungal infection

Cited by 3 publications

References 9 publications

Chronic Lymphocytic Leukemia and Autoimmune Cytopenias: Pathogenesis, Diagnosis and Treatment

Chronic Lymphocytic Leukemia and Autoimmune Cytopenias: Pathogenesis, Diagnosis and Treatment

Leg Ulcers: Expanding the Differential

Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections

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