2019
DOI: 10.1111/iwj.13067
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Pyoderma gangrenosum and tumour necrosis factor alpha inhibitors: A semi‐systematic review

Abstract: Pyoderma gangrenosum (PG) is a rare ulcerative skin disease that presents a therapeutic challenge. Tumour necrosis factor alpha (TNFα) inhibitors have been reported to successfully control PG. Our aim was to systematically evaluate and compare the clinical effectiveness of TNFα inhibitors in adults with PG. A literature search including databases such as PubMed, Embase, Scopus, and Web of Science was conducted, using search terms related to PG and TNFα inhibitors. Studies and case reports were included if pati… Show more

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Cited by 37 publications
(42 citation statements)
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References 204 publications
(191 reference statements)
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“…The favorable outcome in our case was comparable with the prognosis of TNF-α inhibitor-naïve PG patients who later received ADA within 12 weeks of onset. 1,4 A few PG cases receiving two biologics have been described, mainly switching from IFX to ADA. 1,5 One of these patients received secondary ADA treatment in combination with cyclosporin and prednisolone, and the PG ulcer resolved within 16 weeks.…”
Section: Conflict Of Interestmentioning
confidence: 99%
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“…The favorable outcome in our case was comparable with the prognosis of TNF-α inhibitor-naïve PG patients who later received ADA within 12 weeks of onset. 1,4 A few PG cases receiving two biologics have been described, mainly switching from IFX to ADA. 1,5 One of these patients received secondary ADA treatment in combination with cyclosporin and prednisolone, and the PG ulcer resolved within 16 weeks.…”
Section: Conflict Of Interestmentioning
confidence: 99%
“…1,4 A few PG cases receiving two biologics have been described, mainly switching from IFX to ADA. 1,5 One of these patients received secondary ADA treatment in combination with cyclosporin and prednisolone, and the PG ulcer resolved within 16 weeks. 5 In our case, GCAP worked well with secondary ADA.…”
Section: Conflict Of Interestmentioning
confidence: 99%
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