2020
DOI: 10.1007/s10067-020-05285-z
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Pyoderma gangrenosum associated with limited cutaneous systemic sclerosis: a rare case with literature review

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Cited by 2 publications
(5 citation statements)
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“…In terms of the relationship between PG and autoimmune diseases, it is proposed that a commonality in T cell abnormalities and aberrant cytokine production are responsible for the increased incidence of PG in patients with diseases such as rheumatoid arthritis and inflammatory bowel disease (2,4). One study found elevated levels of the cytokines CXC Motif Chemokine Ligand (CXCL) 9, CXCL10, CXCL11, interleukin (IL)-36G, IL-17A and interferon gamma in PG lesions.…”
Section: Pathophysiologymentioning
confidence: 99%
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“…In terms of the relationship between PG and autoimmune diseases, it is proposed that a commonality in T cell abnormalities and aberrant cytokine production are responsible for the increased incidence of PG in patients with diseases such as rheumatoid arthritis and inflammatory bowel disease (2,4). One study found elevated levels of the cytokines CXC Motif Chemokine Ligand (CXCL) 9, CXCL10, CXCL11, interleukin (IL)-36G, IL-17A and interferon gamma in PG lesions.…”
Section: Pathophysiologymentioning
confidence: 99%
“…It was initially thought that these lesions had an infectious origin, since hemolytic streptococci were cultured from the ulcers of patients with pyoderma gangrenosum [1]. Over time, however, it has been discovered that these lesions tend to occur in patients with concomitant systemic autoimmune illnesses such as inflammatory bowel disease, rheumatoid arthritis, systemic sclerosis and systemic lupus erythematosus, suggesting that there is a link between PG and autoimmunity [2,3]. Despite this observation, the exact mechanism of autoimmunity and the genetic mutations which predispose patients to develop these aberrant immune pathways remain poorly understood.…”
Section: Introductionmentioning
confidence: 99%
“…In nearly all of the cases (33/34) described in these reports, the lesions worsened after debridement (Table ). 4,7,[17][18][19][20][21][22][23][24][25][26][27][39][40][41][42][43][44][45][46][47][48][49]51 In addition, 13 reports describe patients with PG on immunosuppressant medication who had lesions debrided and sometimes grafted. None of these patients had any reported worsening of their PG wounds (Table ).…”
Section: Resultsmentioning
confidence: 99%
“…In nearly all of the cases (33/34) described in these reports, the lesions worsened after debridement (Table). 4,7,17–27,39–49,51 …”
Section: Resultsmentioning
confidence: 99%
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