Pyoderma gangrenosum complicating Cogan's syndrome

Abstract

Cogan's syndrome is a rare clinical entity defined by the association of a nonsyphilitic interstitial keratitis and vestibuloauditory dysfunction, typically Menière's disease-like; the condition has been reported in association with a variety of cutaneous diseases. We now report a case of pyoderma gangrenosum complicating Cogan's syndrome in a 57-year-old woman, which then healed dramatically, as more interestingly did the associated uveitis with minocycline therapy.

Cogan’s syndrome with pyoderma gangrenosum: management of two uncommon disorders with aggressive presentation in a patient

“…Boulinguez et al 16 reported a 57-year-old white woman whose uveitis due to CS improved while receiving minocycline for PG in 1998. More recently in 2017, Solano-López et al 17 reported of a white Spanish woman receiving methotrexate, prednisolone and tocilizumab infusion for CS who developed ulcerative PG.…”