Pyoderma Gangrenosum in a Patient with Ulcerative Colitis: A Case Report

Kang, Kyoung In; You, Sun Young; Oh, Sang‐Ha; Kim, Jae Young

doi:10.5223/kjpgn.2009.12.2.240

Cited by 1 publication

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“…[1][2][3][4][5]7 Although iatrogenic KS more often develops in patients undergoing solid organ transplants, there have been rare reports of iatrogenic KS in patients with inflammatory bowel disease (IBD) on immunosuppressants. [1][2][3][4][5][6][8][9][10][11][12][13] Gastrointestinal involvement is most often asymptomatic, although it may present with abdominal pain, diarrhea, and rectal bleeding, resembling an IBD flare. 4,6 Screening endoscopy is not performed in patients without risk factors such as low CD4 ,100 cells/mL, men who have intercourse with men, and presence of cutaneous KS lesions.…”

Section: Introductionmentioning

confidence: 99%

Cyclosporine-Induced Kaposi Sarcoma in a Patient With Ulcerative Colitis

et al. 2021

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Kaposi sarcoma (KS) is an angioproliferative neoplasm associated with human herpesvirus-8. Gastrointestinal KS has been well documented in immunosuppressed solid organ transplant patients, with only 26 iatrogenic cases published in patients with inflammatory bowel disease. We report a 24-year-old patient with ulcerative colitis, maintained on cyclosporine for 2 years, who presented with watery, nonbloody diarrhea and weight loss. Colonoscopy revealed human herpesvirus-8-positive hemorrhagic nodules throughout the colon and terminal ileum, with diffuse lymphadenopathy on computed tomography consistent with KS. As gastrointestinal KS may present with symptoms that mimic inflammatory bowel disease, it is critical to maintain suspicion in patients on prolonged immunosuppression to reduce complications.

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