Pyoderma gangrenosum in pediatric acquired immunodeficiency syndrome

Paller, Amy S.; Sahn, Eleanor E.; Garen, Paul D.; Dobson, Richard L.; Chadwick, Ellen G.

doi:10.1016/s0022-3476(05)82444-8

Cited by 52 publications

(34 citation statements)

References 15 publications

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“…8 Although IBD is the most common underlying cause of pyoderma gangrenosum in children, pyoderma gangrenosum in children can be associated with several other systemic disorders including immunodeficiencies (primary and HIV related), leukemia, hepatitis, and arthritis. 9,10 The occurrence of pyoderma gangrenosum preceding gastrointestinal symptoms in IBD has only been described in a few patients. 6,8,11 Perianal lesions including skin tags, fistulas, fissures, and abscesses are characteristic of Crohn's disease and occur during the course of IBD in 60% to 82% of patients; however, 25% to 30% of patients show perianal lesions before gastrointestinal complaints.…”

Section: Discussionmentioning

confidence: 99%

Asymptomatic Inflammatory Bowel Disease Presenting With Mucocutaneous Findings

et al. 2005

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Section: Discussionmentioning

confidence: 99%

Asymptomatic Inflammatory Bowel Disease Presenting With Mucocutaneous Findings

et al. 2005

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“…It is often associated with a concomitant disease, although up to half of cases are considered idiopathic . Infantile PG is even less common, with only 20 cases reported, 11 of which are described as idiopathic, whereas the others are associated with a spectrum of inflammatory, hematologic, and infectious disorders (Table ) . With this report, we add another patient with infantile PG and review the literature for potential treatments.…”

Section: Introductionmentioning

confidence: 97%

Pyoderma gangrenosum in an infant: A case report and review of the literature

Crouse

McShane

Morrell

et al. 2018

Pediatric Dermatology

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Pyoderma gangrenosum is a neutrophilic dermatosis that is rare in infancy, with only 20 cases reported in the literature. We present a case of infantile pyoderma gangrenosum refractory to topical steroids, tacrolimus, and dapsone as well as systemic steroids and infliximab that is currently well controlled with the addition of oral tacrolimus. To our knowledge, this is the first report of the effective, safe use of oral tacrolimus in combination with infliximab for infantile pyoderma gangrenosum. We review all current cases of infantile pyoderma gangrenosum, as well as tacrolimus and its role in the treatment of this condition.

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“…It has been estimated that 4% of PG cases are in infants and children 1 and, to our knowledge, there are only 12 cases reported in the literature of PG in infants (\1 year of age). [2][3][4][5][6][7][8][9][10][11][12][13] Eight of the reported patients with infantile PG had an underlying medical condition (Table I). Two infants had Takayasu's arteritis, 2,3 one of whom also had sterile osteomyelitis 3 and one further patient had chronic recurrent multifocal osteomyelitis.…”

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confidence: 99%

“…7 There has also been an infant with PG and HIV infection. 8 A further infant had Crohn's disease. 9 The diagnosis of PG in infants is established (as in all age groups) by the clinical presentation, exclusion of alternative diagnoses (especially infectious or malignant processes), and skin biopsy specimens showing the histopathologic changes consistent with PG.…”

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confidence: 99%