Intracranial and spinal subdural empyema was presumptively diagnosed in a 2‐year‐old golden retriever secondary to periorbital abscesses. The patient initially presented to the referring veterinarian for right eye conjunctivitis, intermittent left head turn and reluctance to eat on the left side. The patient then suffered neck trauma from a rope, developing neck pain, left‐sided conscious proprioceptive deficits and right‐sided Horner's syndrome. Most signs resolved with medical management at the referring veterinarian, but neck pain persisted. Severe acute neurological deterioration occurred before presentation at our hospital, culminating in decerebrate rigidity and opisthotonos. Neurological exam revealed multifocal intracranial disease. Magnetic resonance imaging showed periorbital abscesses and extensive intracranial and cervical spinal subdural empyema. The owners elected for euthanasia and declined postmortem examination. Cerebrospinal fluid sampled immediately postmortem confirmed empyema. This is the first report of a presumed case of intracranial and cervical spine subdural empyema caused by periorbital abscesses in a dog.