Pyogenic liver abscess and endogenous endophthalmitis secondary toKlebsiella pneumoniae

Pentecost, Genevieve; Kesterson, Jacob

doi:10.1016/j.ajem.2020.08.028

Cited by 6 publications

(4 citation statements)

References 8 publications

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“…By reviewing relevant literature, the potential mechanism of secondary AP of KP-PLA is proposed here: blood infection: Klebsiella pneumoniae was cultured in the drainage fluid and blood of some KP-PLA patients with secondary extrahepatic infection, suggesting that Klebsiella pneumoniae could cause extrahepatic infection through blood transfer. [3,9] A retrospective study suggested that KP-PLA patients with sepsis were more prone to extrahepatic infection, suggesting that hematogenous infection was a viable route. [10] Biliary tract infection: According to the anatomical structure of liver and pancreas, the intrahepatic and intrahepatic bile ducts eventually converge to the common bile duct and accompany the pancreatic duct to eventually open at the duodenal papilla; part of the common bile duct may converge with the pancreatic duct and open at the duodenal papilla; bacterial infection in the liver may enter the pancreatic tissue through the biliary tract system and lead to AP.…”

Section: Discussionmentioning

confidence: 99%

Occult colon cancer with liver abscess and pancreatitis as the first manifestations: A case report

2023

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Introduction: Klebsiella pneumoniae-induced liver abscess (KP-PLA) is a common type of pyogenic liver abscess, severe acute pancreatitis (SAP) has high mortality, and poor prognosis in advanced colon cancer. There have been no report of SAP complicated with colon cancer after KP-PLA as so far. In this study, we reported a case of SAP secondary to KP-PLA with colon cancer for the first time, so as to provide reference for clinical diagnosis and treatment of these diseases.Patient concerns and diagnosis: A 64-year-old woman with a history of diabetes visited our hospital with abdominal pain for 5 + days. He was diagnosed with KP-PLA a month ago, which had not healed when he was admitted. He was diagnosed with SAP, and histological examination of colonic biopsy confirmed the diagnosis of moderately differentiated adenocarcinoma.Interventions and outcomes: He was treated with intravenous antibiotics and underwent modified endoscopic mucosal resection under colonoscopy. We conducted a 2-month follow-up, and there was no recurrence of liver abscess and pancreatitis. Conclusion:Screening for intestinal tumors is necessary in patients with cryptogenic liver abscess, especially KP-PLA with diabetes.

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Section: Discussionmentioning

confidence: 99%

Occult colon cancer with liver abscess and pancreatitis as the first manifestations: A case report

2023

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“…This trend is especially relevant from the point of view of ophthalmologists because liver abscess due to Klebsiella is associated with the metastatic spread (in 12% of cases, compared to <1% in non-Klebsiella etiologies) [ 1 , 19 ]. The most common manifestations are meningitis and endophthalmitis, however bacteremia, pneumonia, splenic abscess, and necrotizing fasciitis may also occur [ 24 ]. The actual incidence of EE in Klebsiella liver abscess ranges from 0.9 to 7.9% [ 25 ].…”

Section: Primary Source Of Infectionmentioning

confidence: 99%

Endogenous Endophthalmitis—The Clinical Significance of the Primary Source of Infection

Gajdzis

Figuła

Kamińska

et al. 2022

JCM

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Endophthalmitis is a severe form of ocular inflammation. The source of pathogens in endogenous endophthalmitis is located inside the body, and infection spreads hematogenously. Although rare, endogenous endophthalmitis is a very serious condition, as this type of inflammation is very devastating for ocular tissues. Prognosis is very poor, and the patients are often in a serious general condition, so they require special care and an individual approach in the treatment process. Thanks to the knowledge of the risks associated with infections of individual tissues and organs as well as potential pathogens and the clinical picture, it is possible to make a correct diagnosis faster and implement the correct treatment. In the case of endogenous endophthalmitis, reaction time is absolutely crucial for prognosis. In this review, we focus primarily on the importance of the primary source of infection for the course of the disease and prognosis.

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“…Endogenous endophthalmitis (EE) is a rare and serious complication of PLA and often appears with eye symptoms before PLA 8,19,20 . Despite continued negative blood cultures, the patient's presentation may be consistent with invasive liver abscess syndrome, with associated EE qualifying as a systemic manifestation of disease 21 . A meta‐analysis estimates the actual incidence of EE among PLA patients, where EE is reported in approximately one out of every 22 patients with Klebsiella pneumoniae pyogenic liver abscess.…”

Section: Introductionmentioning

confidence: 99%

“… 8 , 19 , 20 Despite continued negative blood cultures, the patient's presentation may be consistent with invasive liver abscess syndrome, with associated EE qualifying as a systemic manifestation of disease. 21 A meta‐analysis estimates the actual incidence of EE among PLA patients, where EE is reported in approximately one out of every 22 patients with Klebsiella pneumoniae pyogenic liver abscess. K1 capsular serotype infection was an independent risk factor.…”

Section: Introductionmentioning

confidence: 99%

Pyogenic liver abscess complicated with endogenous endophthalmitis caused by Klebsiella pneumoniae: A case report and Literature Review

Chen

Gong

Song

et al. 2023

Immunity Inflam & Disease

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Objective Pyogenic liver abscess (PLA) is a common surgical infectious disease caused by various pathogens. Klebsiella pneumoniae is a relatively recent cause, often affecting patients with low immunity. Endogenous endophthalmitis (EE), a rare and serious complication of PLA, may appear with eye symptoms before PLA. By reviewing a case of Klebsiella pneumoniae‐induced PLA complicated with EE, we want to summarize the information about the characteristics, causes, and complications of PLA based on the literature review. Methods This case report describes a 37‐year‐old male who had fever high to 39°C for 10 days experienced blurred vision followed by nonlight perception vision. He reported a history of diabetes irregularly taking oral medications and insulin therapy. Imaging examination found a large low‐density area in the right lobe of the liver with an unclear border and vague surrounding fat gap. The blood culture was not positive. The culture of the drainage fluid from the liver puncture showed Klebsiella pneumonia. Blood and liver puncture drainage fluid were sent for microbial high‐throughput gene detection with next‐generation sequencing technology (NGS), which confirmed the diagnosis of Klebsiella pneumoniae‐induced PLA complicated with EE. Results The patient's surgical incision had healed well at discharge, and he could feel light at his left eye. But the patient was lost to follow‐up since the third month after discharge. Conclusion By reviewing this case and summarize the information about the characteristics, causes, and complications of PLA based on the literature review, we concluded that it is necessary to promptly perform liver puncture drainage and empirically use antibiotics for patients with PLA, especially those with poor glycemic control, to avoid serious complications such as EE.

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Pyogenic liver abscess and endogenous endophthalmitis secondary toKlebsiella pneumoniae

Cited by 6 publications

References 8 publications

Occult colon cancer with liver abscess and pancreatitis as the first manifestations: A case report

Occult colon cancer with liver abscess and pancreatitis as the first manifestations: A case report

Endogenous Endophthalmitis—The Clinical Significance of the Primary Source of Infection

Pyogenic liver abscess complicated with endogenous endophthalmitis caused by Klebsiella pneumoniae: A case report and Literature Review

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