Pyogenic Liver Abscess as the Initial Manifestation of Underlying Hepatocellular Carcinoma

TREM-1 Promotes Survival during Klebsiella pneumoniae Liver Abscess in Mice

“…In the past 3 decades, K. pneumoniae has become the dominant cause of pyogenic liver abscesses and has contributed to the endemicity of the disease in Taiwan (6)(7)(8)(9)(10). K. pneumoniae liver abscess (KPLA) is also responsible for the majority of cases of liver abscess in other Asian countries, especially South Korea (11,12) and Singapore (13).…”

Pyogenic Liver Abscess as a Warning Sign for Primary Liver Cancer: A Nationwide Population-based Study

“…Furthermore, histopathologic examination should be taken into consideration when physicians raised concern about the possibility of PLC. Second, in the study conducted by Lin et al, patients diagnosed with HCC who initially manifested as PLA had a worse prognosis than those without PLA (Lin et al, 2011). They supposed that management of PLA may lead to delayed diagnosis and that drainage procedures may cause tumor to spread if physicians are not on heightened alert for PLC.…”

“…PLA has been regarded as the initial manifestation of hepatobiliary neoplasms in several reports with a range of 3 to 10 cases (Okuda et al, 1991;Yeh et al, 1998; Chong et al, 2009;Huang et al, 2009;Li et al, 2012). Lin et al reported 2.15% of patients with underlying hepatocellular carcinoma (HCC) presented with PLA as the initial manifestation (Lin et al, 2011). They arbitrarily defined patients with PLA as the initial manifestation of underlying HCC when the diagnosis date of HCC was within 60 days of diagnosis of PLA, which might lead to misclassification bias regarding HCC status (Copeland et al, 1977).…”

Hepatocellular carcinoma presenting as liver abcess

“…1 It affects mostly adults, but can also occur in children. The average age at diagnosis in adults is 55 years, with male preponderance.…”

“…Hepatocellular carcinoma (HCC) is the commonest primary malignant tumor of the liver.HCC presenting as a pyogenic liver abscess is reported but is uncommon and rarely addressed in literature 1 . It is challenging to diagnose HCC presenting as a pyogenic abscess.…”