Pyometra in Small Animals 2.0

Hagman, Ragnvi

doi:10.1016/j.cvsm.2022.01.004

Cited by 39 publications

(101 citation statements)

References 94 publications

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“…Although the pathogenesis of pyometra is poorly understood, previous studies have suggested that the intestine is the main source of E. coli strains that ascend into the uterus [ 1 , 2 , 7 ]. This study reinforces this hypothesis, as bitches with E. coli pyometra were more likely to harbor E. coli strains from phylogroup B2 in the rectal swab when compared to the group of bitches without E. coli pyometra.…”

Section: Discussionmentioning

confidence: 99%

“…Pyometra is the most frequently occurring reproductive disease in bitches, affecting up to 25% of uncastrated females [ 1 , 2 ]. The disease is characterized by bacterial infection of the uterus with local and systemic clinical manifestations that can lead to death [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, despite its relevance, the pathogenesis of this disease remains poorly understood. It is believed that bacterial species causing pyometra ascend from the intestinal tract of females, causing infections [ 1 , 2 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Extraintestinal pathogenic Escherichia coli (ExPEC) is the most common pathogen involved in canine pyometra and has been reported in 57–100% of cases [ 1 , 2 , 6 , 7 ]. These isolates are phylogenetically and epidemiologically distinct from E. coli strains commonly found in intestinal commensals that cause diarrhea and other gastrointestinal disorders [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although the intestinal ascension of E. coli strains is currently the most accepted hypothesis in the pathogenesis of canine pyometra [ 1 , 2 , 7 ], no studies have evaluated the influence of the dog diet on the specific colonization of ExPEC strains. In the last decade, an increasing number of owners have been feeding their dogs and cats raw meat-based diets (RMBDs), instead of regular commercial dry feed [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Characterization of Escherichia coli in Dogs with Pyometra and the Influence of Diet on the Intestinal Colonization of Extraintestinal Pathogenic E. coli (ExPEC)

Xavier

Silva

Trindade

et al. 2022

Veterinary Sciences

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Despite its high frequency and clinical relevance, the pathogenesis of canine pyometra remains poorly understood. The most accepted hypothesis is that bacteria involved ascend from the intestinal tract, causing the uterine infection. Extraintestinal pathogenic Escherichia coli (ExPEC) is the most frequent pathogen in canine pyometra, accounting for 57–100% of cases. The aim of the present study was to determine the frequency of phylogenetic groups and virulence factors in E. coli strains isolated from the uterine and rectal swabs of bitches with pyometra (n = 72) and from rectal swabs from healthy bitches fed commercial dry feed (n = 53) or a raw meat-based diet (RMBD; n = 38). A total of 512 strains of E. coli were isolated and divided into five categories according to the origin of the sample: 120 isolates from the uterine content of dogs with E. coli pyometra, 102 from the feces of bitches with E. coli pyometra, 75 from the feces of bitches without E. coli pyometra, 130 feces samples from healthy dogs fed commercial feed, and 85 feces samples from healthy dogs fed a raw meat-based diet. E. coli strains belonging to the B2 phylogroup and positive for virulence factor genes associated with adhesion (fimbriae type P [papC]) and production of toxins (α-hemolysin [hlyA] and uropathogenic specific protein [usp]) predominated in the uterine content and rectal swabs of bitches with E. coli pyometra. Interestingly, a lower growth rate of E. coli from the B2 phylogroup was observed in dogs fed a RMBD than in those fed commercial dry feed. The present study suggests that intestinal colonization by certain types of E. coli could be a risk factor for the occurrence of E. coli pyometra in bitches and that diet can influence intestinal colonization by such strains.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Characterization of Escherichia coli in Dogs with Pyometra and the Influence of Diet on the Intestinal Colonization of Extraintestinal Pathogenic E. coli (ExPEC)

Xavier

Silva

Trindade

et al. 2022

Veterinary Sciences

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Pyometra

Matz

2024

Techniques in Small Animal Soft Tissue, Orthopedic, and Ophthalmic Surgery

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Antimicrobial use in the surgical treatment of canine pyometra: A questionnaire survey of Arizona‐licensed veterinarians

Lavin

Maki

2023

Veterinary Medicine & Sci

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Background: Recent studies and consensus statements in veterinary and human medicine recommend more judicious use of antimicrobials. While guidelines have been provided for some veterinary diseases, others have poorly elucidated guidelines. Postoperative treatment of canine pyometra is a condition with minimal guidelines regarding antimicrobial use. Objective: To identify and investigate patterns of antimicrobial use following surgically treated canine pyometra. Methods: A 23-question survey, sent to 863 small and mixed animal practitioners, investigated demographics, patterns of antibiotic use, rate of culture submission and participant's recollection of outcomes of surgically treated pyometra cases. Responses were analysed for relationships between demographics, patterns of antibiotic use and culture results to better understand reasoning for antibiotic protocols. Results: One hundred and fifty-two responses were received. Overall, 76% of veterinarians stated they always use preoperative and perioperative antibiotics, and 74% stated they always use postoperative antibiotics. A total of 16 different antibiotics were reported. Twelve per cent of respondents regularly submitted a culture. Culture submission was impacted by cost, prior experience, poor owner compliance, result turnaround time and anticipated results. Conclusions: Most respondents always used antibiotics and rarely or never submitted a culture. To optimise patient care, future clinical studies are needed to determine specific guidelines for the use of culture and antibiotics in the treatment of canine pyometra following ovariohysterectomy.

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Pyometra in Small Animals 2.0

Cited by 39 publications

References 94 publications

Characterization of Escherichia coli in Dogs with Pyometra and the Influence of Diet on the Intestinal Colonization of Extraintestinal Pathogenic E. coli (ExPEC)

Characterization of Escherichia coli in Dogs with Pyometra and the Influence of Diet on the Intestinal Colonization of Extraintestinal Pathogenic E. coli (ExPEC)

Pyometra

Antimicrobial use in the surgical treatment of canine pyometra: A questionnaire survey of Arizona‐licensed veterinarians

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