“…5 Systemic immunosuppression (HIV infection, immunosuppressive therapies, chronic renal disease), collagen-vascular diseases or focal muscle frailty (past surgery or trauma, ischemia, foreign bodies) might represent underlying risk factors for tuberculous pyomyositis. 2,9,10 Nevertheless, soft tissue involvement without a clinically and/or radiologically apparent primary focus is extremely rare, particularly in immunocompetent patients. In our patient, multifocal muscle seeding likely resulted from hematogenous spread from an undetected healed focus.…”