Pyomyositis associated with chemotherapy for endometrial cancer: a case report

Nakao, Yasuo; Yokoyama, Masatoshi; Nishiyama, Satoshi; Hashiguchi, Mariko; Aihara, Satomi; Yasunaga, Makio; Noguchi, Mitsuyo; Iwasaka, Tsuyoshi

doi:10.1186/1477-7819-11-45

Cited by 6 publications

(2 citation statements)

References 6 publications

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“…Two such cases have been described in the setting of paclitaxel treatment for endometrial cancer. Both patients presented classically with fever, pain, and decreased range of motion, but due to the rarity of the diagnosis appropriate treatment including drainage of the abscess collection was delayed [ 25 , 26 ]. Our patient did not present with fever or leukocytosis; there was no evidence of abscesses which were noted on MRI and did not improve with antibiotics.…”

Section: Discussionmentioning

confidence: 99%

A Case of Docetaxel Induced Myositis and Review of the Literature

Perel-Winkler

Belokovskaya

Amigues

et al. 2015

Case Reports in Rheumatology

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In phase I and II trials taxane chemotherapeutic agents reported side effects, including myelosuppression, peripheral edema, and fluid retention. With further use of these agents, studies in the late 1980s and early 1990s began to report peripheral neuropathy and proximal muscle weakness as common complaints, the later with unexplained pathophysiology. We report a 65-year-old Hispanic woman with estrogen receptor (ER) and progesterone receptor (PR) positive invasive ductal breast carcinoma who presented with right thigh pain and swelling eight days after her third infusion of docetaxel (a taxane chemotherapeutic) and cyclophosphamide. Laboratory findings were notable for elevation in creatine phosphokinase (CPK), aldolase, and erythrocyte sedimentation rate (ESR); a magnetic resonance imaging (MRI) of her lower extremities showed evidence of bilateral muscle edema involving the anterior compartment muscles of the thighs. A workup to rule out other causes of myositis was negative. Docetaxel was not reintroduced and the patient improved with corticosteroids. Since 2005 this is, to our knowledge, the fifth reported case of docetaxel related inflammatory myositis. Taxanes have been noted to cause disabling but transient arthralgias and myalgias; it is important to consider the possibility of inflammatory myopathy as a possible complication in patients undergoing treatment with these agents.

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Section: Discussionmentioning

confidence: 99%

A Case of Docetaxel Induced Myositis and Review of the Literature

Perel-Winkler

Belokovskaya

Amigues

et al. 2015

Case Reports in Rheumatology

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“…Although pyomyositis has recently been recognized as a rare but important complication in patients with hematological malignancies undergoing chemotherapy [ 3 ], to the best of our knowledge, only 10 such cases in patients with solid tumors undergoing chemotherapy have been reported [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. A patient with advanced pyomyositis, requiring interventional treatment with percutaneous or operative drainage and debridement, may have to defer or interrupt a potentially life-saving chemotherapeutic regimen.…”

Section: Introductionmentioning

confidence: 99%

Pyomyositis in a Patient Undergoing Chemotherapy for Gastric Cancer: A Case Report and Literature Review

Nakayama¹,

Sugiyama²,

Yamamoto

et al. 2021

Case Rep Oncol

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Pyomyositis has recently been recognized as a primary infection of the large skeletal muscles, and it is often accompanied by single or multiple intramuscular abscess formation. Immunocompromised patients, including those with diabetes mellitus, human immunodeficiency virus infection, and cancer, as well as those undergoing chemotherapy, are at a greater risk of developing pyomyositis. A 78-year-old Japanese man with recurrent gastric cancer being treated with chemotherapy presented with sudden-onset pain in his left lower extremity while undergoing a second-line regimen with irinotecan. T2-weighted magnetic resonance imaging (MRI) showed an abnormally high-intensity signal in the left internal and external obturator muscles, a finding consistent with pyomyositis. Following intensive antibiotic treatment, the patient recovered completely and was able to resume chemotherapy with irinotecan. For a patient who developed pyomyositis during chemotherapy for gastric cancer, early diagnosis using MRI followed by administration of timely intensive antibiotic therapy resulted in complete recovery.

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Carboplatin/docetaxel

2013

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Pyomyositis associated with chemotherapy for endometrial cancer: a case report

Cited by 6 publications

References 6 publications

A Case of Docetaxel Induced Myositis and Review of the Literature

A Case of Docetaxel Induced Myositis and Review of the Literature

Pyomyositis in a Patient Undergoing Chemotherapy for Gastric Cancer: A Case Report and Literature Review

Carboplatin/docetaxel

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