Pyostomatitis Vegetans: Cellular Immune Profile and Expression of IL-6, IL-8 and TNF-α

Ficarra, Giuseppe; Baroni, Gianna; Massi, Daniela

doi:10.1007/s12105-009-0149-7

Cited by 14 publications

(19 citation statements)

References 24 publications

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“…Symptoms of burning and pain may be present. 84 Other than oral cavity, mucosal membranes at the vaginal, nasal, and rarely periocular areas can also be involved. 85 Histopathologically, PSV is characterized by epithelial acanthosis and superficial ulceration with intraepithelial and/or subepithelial microabscesses.…”

Section: Pyostomatitis Vegetansmentioning

confidence: 99%

“…85 Histopathologically, PSV is characterized by epithelial acanthosis and superficial ulceration with intraepithelial and/or subepithelial microabscesses. 83,84 PSV usually parallels the activity of the underlying bowel disease, 84 and there are reports of mucosal lesions after regression of IBD flare or after surgical treatment of IBD.…”

Section: Pyostomatitis Vegetansmentioning

confidence: 99%

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Cutaneous Manifestations in Patients With Inflammatory Bowel Diseases

Marzano

Borghi

Stadnicki

et al. 2014

Inflammatory Bowel Diseases

120

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The skin is one of the most common extraintestinal organ system affected in patients with inflammatory bowel disease (IBD), including both Crohn's disease and ulcerative colitis. The skin manifestations associated with IBD are polymorphic and can be classified into 4 categories according to their pathophysiology: (1) specific, (2) reactive, (3) associated, and (4) induced by IBD treatment. Cutaneous manifestations are regarded as specific if they share with IBD the same granulomatous histopathological pattern: perianal or metastatic Crohn's disease (commonly presenting with abscesses, fistulas or hidradenitis suppurativa-like features) is the prototype of this setting. Reactive cutaneous manifestations are different from IBD in the histopathology but have close physiopathological links: pyoderma gangrenosum, a neutrophil-mediated autoinflammatory skin disease typically manifesting as painful ulcers, is the paradigm of this group. Among the cutaneous diseases associated with IBD, the most commonly seen are erythema nodosum, a form of panniculitis most commonly involving bilateral pretibial areas, and psoriasis, a T helper 1/T helper 17-mediated erythematous squamous inflammatory disease. Finally, the number of cutaneous adverse reactions because of IBD therapies is progressively increasing. The most frequent drug-induced cutaneous manifestations are psoriasis-like, eczema-like, and lichenoid eruptions, as well as cutaneous lupus erythematosus for biologics, and nonmelanoma skin cancer, mainly basal cell and squamous cell carcinomas for thiopurines.

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Section: Pyostomatitis Vegetansmentioning

confidence: 99%

Section: Pyostomatitis Vegetansmentioning

confidence: 99%

Cutaneous Manifestations in Patients With Inflammatory Bowel Diseases

Marzano

Borghi

Stadnicki

et al. 2014

Inflammatory Bowel Diseases

120

View full text Add to dashboard Cite

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“…In contrast to EN and PG which have been shown to have a female predilection, there is a male predominance in PSV with a ratio ranging from 2:1 to 3:1 and the majority of cases occur in Caucasians (Femiano et al, 2009; Ficarra et al, 2010). The pathogenesis of PSV is not known yet, although abnormal immunological responses and/or microbial factors are suggested (Kethu, 2006; Femiano et al, 2009; Ficarra et al, 2010).…”

Section: Reactive Cutaneous Manifestations Of Ibdmentioning

confidence: 99%

“…McCarthy (1949) proposed the term “pyostomatitis vegetans” after he observed similar lesions isolated in the oral cavity (McCarthy, 1949; Femiano et al 2009). Recently these two entities are considered to be variants of the same disease termed pyodermatitis–pyostomatitis vegetans (PPV; Ficarra et al, 2010). PDV and PSV (or together as a group PPV) are rare cutaneous manifestation of IBD (Storwick et al, 1994; Femiano et al, 2009).…”

Section: Reactive Cutaneous Manifestations Of Ibdmentioning

confidence: 99%

Skin Manifestations of Inflammatory Bowel Disease

2012

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Inflammatory bowel disease (IBD) is a disease that affects the intestinal tract via an inflammatory process. Patients who suffer from IBD often have diseases that affect multiple other organ systems as well. These are called extraintestinal manifestations and can be just as, if not more debilitating than the intestinal inflammation itself. The skin is one of the most commonly affected organ systems in patients who suffer from IBD. The scientific literature suggests that a disturbance of the equilibrium between host defense and tolerance, and the subsequent over-activity of certain immune pathways are responsible for the cutaneous disorders seen so frequently in IBD patients. The purpose of this review article is to give an overview of the types of skin diseases that are typically seen with IBD and their respective pathogenesis, proposed mechanisms, and treatments. These cutaneous disorders can manifest as metastatic lesions, reactive processes to the intestinal inflammation, complications of IBD itself, or side effects from IBD treatments; these can be associated with IBD via genetic linkage, common autoimmune processes, or other mechanisms that will be discussed in this article. Ultimately, it is important for healthcare providers to understand that skin manifestations should always be checked and evaluated for in patients with IBD. Furthermore, skin disorders can predate gastrointestinal symptoms and thus may serve as important clinical indicators leading physicians to earlier diagnosis of IBD.

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“…Cependant, l'IFD peut se montrer faiblement positive avec des dépôts de C3, d'IgG et d'IgA au niveau de la membrane basale ou à la surface des kératinocytes en réponse à des lésions épi-théliales [6]. Ficarra et al montrent que la présence importante de lymphocytes T CD8+ sur les coupes histologiques, associée aux macrophages et aux polynucléaires neutrophiles, semble être responsable de ces lésions épithéliales et des ulcé-rations caractéristiques de la PV rendant parfois l'immunohistochimie positive, induisant un diagnostic erroné de pemphigus végétant [7].…”

Section: Introductionunclassified

Pyostomatite végétante de la muqueuse orale : cas clinique et revue de la littérature

Guillerminet

Lepreux

Mittler

et al. 2015

Med Buccale Chir Buccale

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-Pyostomatitis vegetans: case report and literature review. Introduction: Pyostomatitis vegetans is a rare dermatosis which is manifested by yellowish-white pustules and inflammatory vesiculous lesions of the oral mucosa in the gum, the vestibule, the soft and hard palate, and sometimes the lips. PV is often associated with inflammatory bowel chronic diseases (IBDs) such as ulcerative colitis and Crohn's disease. Observation: An 80-year-old patient with Crohn's disease consulted for linear ulceration localized on the lower labial vestibule of the left cheek and on the right upper vestibule. The PV diagnosis was made after biopsy and the lesions regressed under local corticosteroid application. Discussion: The characteristic symptoms and histology (negative direct and indirect immunofluorescence) enable the diagnosis of PV and eliminate pemphigus vegetans and pyoderma gangrenosum. Peripheral eosinophilia and eosinophils on a histological section may be useful for monitoring disease activity. Treatment is based on local or systemic corticosteroids depending on the intensity of the oral and gastrointestinal involvement. Conclusion: Upon discovery of PV lesions, testing for IBDs is critical in order to establish a treatment as early as possible.

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Pyostomatitis Vegetans: Cellular Immune Profile and Expression of IL-6, IL-8 and TNF-α

Cited by 14 publications

References 24 publications

Cutaneous Manifestations in Patients With Inflammatory Bowel Diseases

Cutaneous Manifestations in Patients With Inflammatory Bowel Diseases

Skin Manifestations of Inflammatory Bowel Disease

Pyostomatite végétante de la muqueuse orale : cas clinique et revue de la littérature

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