Pyramidal anterior polar cataracts11None of the authors has any proprietary interests that could cause or be perceived to be a conflict of interest with this study.

Wheeler, David T.; Mullaney, Paul; Awad, Abdulaziz; Zwaan, Johan

doi:10.1016/s0161-6420(99)90540-7

Cited by 29 publications

(5 citation statements)

References 8 publications

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“…[1, 5, 8, 9]. In our population, 38.7% of the patients had other ocular abnormalities in addition to the anterior lens opacities.…”

Section: Discussionmentioning

confidence: 95%

“…Generally, they remain stationary in size but may progress to requiring surgery [3]. Although need for cataract surgery is infrequent in these patients, progression or increase in the size of the cataracts has been described [3, 5]. …”

Section: Discussionmentioning

confidence: 99%

“…The patients were identified through an ICD-9 search of the electronic medical records. Cataracts were classified according to their sub-type (polar, subcapsular, and pyramidal), size (<1 mm, 1-3 mm, or >3 mm), laterality, and location on the lens (central or para-central) based on previous classification in the literature [5]. Data were also collected regarding gender, age at diagnosis, length of follow-up, associated ocular or systemic conditions, ocular alignment, refractive error, presence and treatment of amblyopia, and surgical intervention.…”

Section: Methodsmentioning

confidence: 99%

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Characteristics of Anterior Lens Opacities in Children

Dixit

Puente

Yen

2017

TOOPHTJ

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Background:Anterior lens opacities (ALO) are found in 3-14% of pediatric patients with cataracts. No clear guidelines exist in the management and treatment of these cataracts.Objective:To evaluate pediatric patients with anterior lens opacities and assess rate of amblyopia and need for surgery over time.Methods:A retrospective chart review was performed on patients with unilateral and bilateral anterior lens opacities (ALOs) seen between January 2008 and December 2014. Size, location, and type of ALO were noted. Refractive error, necessity for treatment of amblyopia, and interventions were recorded.Results:A total of 31 patients were included in the study. 17 patients had unilateral ALOs and 14 had bilateral ALOs. The majority of the cataracts (90.3%) were centrally located. The most common type of cataract was the polar type of cataract and the vast majority (48.4%) was < 1mm in size. 38.7% of patients had concurrent ocular conditions and 9.7% had systemic associations. 28.6% of patients with bilateral cataracts and 35.3% of the patients with unilateral cataracts were treated for amblyopia. Three patients required cataract surgery.Conclusion:About half of anterior lens opacities are less than 1mm in size and the majority are of the polar type. Risk of amblyopia in these patients is higher than in the general population. Anisometropia is the most common cause of amblyopia. Ocular associations are seen at a relatively high frequency and systemic associations can occur but are uncommon. The need for surgical intervention is infrequent; however, growth of ALOs and associated cortical changes may be risk factors for surgery.

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“…[1, 5, 8, 9]. In our population, 38.7% of the patients had other ocular abnormalities in addition to the anterior lens opacities.…”

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Characteristics of Anterior Lens Opacities in Children

Dixit

Puente

Yen

2017

TOOPHTJ

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“…This could possibly explain the irregular astigmatism seen in our patients. 19 Furthermore, even though refractive errors in aniridia do vary, anterior congenital cataracts are usually associated with variable astigmatism. 20…”

Section: Discussionmentioning

confidence: 99%

Case series: Pyramidal cataracts, intact irides and nystagmus from three novel PAX6 mutations

Chauhan

Medsinge

Baumgartner

et al. 2018

American Journal of Ophthalmology Case Reports

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PurposeTo investigate the association between novel PAX6 mutations to bilateral anterior pyramidal congenital cataracts (APyC), complete and intact irides, and nystagmus.ObservationsThis is a retrospective observational case series in a multi-center setting with genetic testing. Three female patients were diagnosed with bilateral APyC, intact irides and nystagmus. Genetic testing identified the three patients had novel missense mutations in PAX6 – c.128C > T; p.Ser43Phe (S43F), c. 197T > A; p.Ile66Asn (I66N) and c.781C > G; p.Arg261Gly (R261G).Conclusions and importanceThis study demonstrates a novel phenotype of bilateral APyC, intact irides, and nystagmus in whom genetic testing for PAX6 identified novel missense mutations (S43F, I66N, R261G) in highly conserved DNA-binding domains. Implications of understanding why the iris is present in these cases is discussed.

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“…Anterior pyramidal cataracts have been reported as unilateral or bilateral presentations at birth but may progress from typical polar opacities. There are no systemic associations . Rarely, a spontaneous dehiscence of the pyramid into the anterior chamber may occur …”

mentioning

confidence: 99%

Pediatric Anterior Pyramidal Polar Cataract

Kurup

2017

JAMA Ophthalmol

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A healthy infant girl presented with bilateral 1-mm anterior polar cataracts. Initial monitoring every 2 to 3 months was recommended, but she did not return until she was 16 months old, at which point the cataracts had prominent pyramidal growth with a significant cortical component (Figure). Her visual acuity was 0.64 cycle/cm OD using Teller acuity cards, and she would only fix and follow OS. The remainder of her examination was unremarkable, including B-scan ultrasonography of the posterior segment. She underwent lensectomy/anterior vitrectomy in each eye and used aphakic con-tact lenses. She was 3 years old at her last visit and had inconsistent follow-up and poor compliance with amblyopia management. Her visual acuity was 20/60 OD and 20/250 OS, complicated by a sensory left esotropia.Anterior pyramidal cataracts have been reported as unilateral or bilateral presentations at birth but may progress from typical polar opacities. There are no systemic associations. 1-3 Rarely, a spontaneous dehiscence of the pyramid into the anterior chamber may occur. 4,5

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Pyramidal anterior polar cataracts11None of the authors has any proprietary interests that could cause or be perceived to be a conflict of interest with this study.

Cited by 29 publications

References 8 publications

Characteristics of Anterior Lens Opacities in Children

Characteristics of Anterior Lens Opacities in Children

Case series: Pyramidal cataracts, intact irides and nystagmus from three novel PAX6 mutations

Pediatric Anterior Pyramidal Polar Cataract

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