Pyranonaphthoquinone and anthraquinone derivatives from Ventilago harmandiana and their potent anti-inflammatory activity

2-Bromoanthraquinone as a highly efficient photocatalyst for the oxidation of sec-aromatic alcohols: experimental and DFT study

“…8,9 Anthraquinone is widely used in the pharmaceutical and chemical industries, in peroxide production, and in anti-cancer, anti-inammatory, antinociceptive activities, among others. [10][11][12][13] In addition, AQs are the most abundant group of dyes apart from azo dyes. As one of the cheapest organic dyes, AQs have been developed very quickly during the past decades 14 for their wide range of colors.…”

Data_Sheet_1.docx

“…The plant Ventilago genus of the Rhamnaceae family contains more than 40 species and is found across India, South Asia (Cooke and Johnson, 1963), and recently in Thailand (Kongsriprapan et al, 2012). Various members of the Ventilago genus have been used as traditional medicines for numerous therapeutic treatments, e.g., diabetes, wounds, psoriasis, AIDS, diuretics, and arthritis (Kongsriprapan et al, 2012;Molee et al, 2018), as well as anti-inflammation in both animal and cell line studies (Wang et al, 2016;Panthong et al, 2020). Ventilago harmandiana Pierre (V. harmandiana) is an endemic plant that is found locally in the southern part of Thailand.…”

“…Ventilago harmandiana Pierre (V. harmandiana) is an endemic plant that is found locally in the southern part of Thailand. In over 15 years of our research on the specialized metabolites from this plant, we have discovered 10 novel pyranonaphthoquinones (PNQs) ( Supplementary Figures S1A-J), an anthraquinone (ATQ) (ventilanone K, Supplementary Figure S1K), and 10 known anthraquinone (ATQ) derivatives ( Supplementary Figures S2A-J) in V. harmandiana and V. maingayi (Leewanich, 2005;Panthong et al, 2020). Among these, PNQs represent an interesting class of specialized metabolites with a basic skeleton consisting of a fused three-ring structure composed of a pyran, a quinone, and a benzene ring.…”

“…Our recent study highlighted the cytotoxic and anti-inflammatory properties of these PNQs isolated from V. harmandiana. Specifically, PNQ-318A (Figure 1) demonstrated very promising activity for the future development of anti-inflammatory agents (Panthong et al, 2020).…”

“…Fractions that exhibit promising activity characteristics are further isolated and purified. The purified compounds are subjected to a combination of various characterization techniques, such as nuclear magnetic resonance (NMR), mass spectrometry (MS), and chiroptical spectroscopic methods for structural determination (Wolfender et al, 2019;Panthong et al, 2020). Although these long processes are very effective, they are often complex, tedious, costly, and time consuming.…”