Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase

Sun, Xiaohui; Li, Yaxin; He, Wenrong; Ji, Chuanyi; Xia, Peixue; Wang, Yichuan; Du, Shuo; Li, Hongjiang; Raikhel, Natasha V.; Xiao, Junyu; Guo, Hongwei

doi:10.1038/ncomms15758

Cited by 80 publications

(58 citation statements)

References 73 publications

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“…The longer vase life of the flowers treated with 2,4-PDCA may be caused by the pronounced inhibition of ethylene production as compared with the acceleration of flower opening. Recently, Sun et al (2017) reported that 2-PCA blocks ethylene biosynthesis by inhibiting the ACC oxidase action, but 3-PCA does not. Therefore, 3-PCA, and probably 3-PCA amide, promoted only flower opening, but did not inhibit ethylene production, resulting in a shorter vase life than that of 2,4-PDCA-treated flowers.…”

Section: Resultsmentioning

confidence: 99%

Promotion of Flower Opening of Spray-type Carnation Cut Flowers by 3-Pyridinecarboxylic Acid, a Simple Analog of Pyridinedicarboxylic Acids (PDCAs) Including 2,3- and 2,4-PDCAs

Satoh

Nomura

2019

Hortic J

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Pyridinedicarboxylic acid (PDCA) analogs extend the vase life of spray-type (SP) carnation flowers by accelerating flower opening and retarding senescence. Among the PDCA analogs, 2,3-PDCA and 2,4-PDCA are equally and highly effective. In the present study, we characterized the promotion of flower opening by PDCAs and their analogs, pyridinecarboxylic acids. The present results showed that 3-pyridinecarboxylic acid (3-PCA), and its derivative, 3-PCA amide, are most active in accelerating flower opening of 'Light Pink Barbara' carnation cut flowers. 3-PCA treatment promoted flower opening in cut flowers of many SP carnation cultivars, that had been stored dry at 2-4°C for 3 weeks and resulted in extension of their display time.

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Section: Resultsmentioning

confidence: 99%

Promotion of Flower Opening of Spray-type Carnation Cut Flowers by 3-Pyridinecarboxylic Acid, a Simple Analog of Pyridinedicarboxylic Acids (PDCAs) Including 2,3- and 2,4-PDCAs

Satoh

Nomura

2019

Hortic J

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“…S13). However, additional data are needed to exclude the inhibition of enzymes in auxin biosynthesis pathway directly by AVG (Sun et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Phosphoethanolamine N‐methyltransferase 1 contributes to maintenance of root apical meristem by affecting ROS and auxin‐regulated cell differentiation in Arabidopsis

et al. 2019

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Summary The continuous growth of roots requires the balance between cell division and differentiation. Reactive oxygen species (ROS) and auxin are important regulators of root development by affecting cell division and differentiation. The mechanism controlling the coordination of cell division and differentiation is not well understood. Using a forward genetic screen, we isolated a mutant, defective primary root 2 (dpr2), defective in root apical meristem (RAM) maintenance. The DPR2 gene encodes phosphoethanolamine N‐methyltransferase 1 (PEAMT1) that catalyzes phosphocholine biosynthesis in Arabidopsis. We characterized the primary root phenotypes of dpr2 using various marker lines, using histochemical and pharmacological analysis to probe early root development. Loss‐of‐function of DPR2/PEAMT1 resulted in RAM consumption by affecting root stem cell niche, division zone, elongation and differentiation zone (EDZ). PIN‐FORMED (PIN) protein abundance, PIN2 polar distribution and general endocytosis were impaired in the root tip of dpr2. Excess hydrogen peroxide and auxin accumulate in the EDZ of dpr2, leading to RAM consumption by accelerating cell differentiation. Suppression of ROS over‐accumulation or inhibition of auxin signalling partially prevent RAM differentiation in dpr2 after choline starvation. Taken together, we conclude that the EDZ of the root tip is most sensitive to choline shortage, leading to RAM consumption through an ROS–auxin regulation module.

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“…a,b), suggesting that basal levels of endogenous ethylene are required to maintain normal root elongation. To further examine whether the short root phenotype of the osdof15 mutants was due to the overproduction of ethylene, we used the ethylene biosynthesis inhibitor POA (Sun et al ., ). Application of 50 μM POA largely rescued the short root phenotype of osdof15 (Figs c,d, S5a,b).…”

Section: Resultsmentioning

confidence: 97%

Rice OsDOF15 contributes to ethylene‐inhibited primary root elongation under salt stress

et al. 2019

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Summary In early seedlings, the primary root adapts rapidly to environmental changes through the modulation of endogenous hormone levels. The phytohormone ethylene inhibits primary root elongation, but the underlying molecular mechanism of how ethylene‐reduced root growth is modulated in environmental changes remains poorly understood. Here, we show that a novel rice (Oryza sativa) DOF transcription factor OsDOF15 positively regulates primary root elongation by regulating cell proliferation in the root meristem, via restricting ethylene biosynthesis. Loss‐of‐function of OsDOF15 impaired primary root elongation and cell proliferation in the root meristem, whereas OsDOF15 overexpression enhanced these processes, indicating that OsDOF15 is a key regulator of primary root elongation. This regulation involves the direct interaction of OsDOF15 with the promoter of OsACS1, resulting in the repression of ethylene biosynthesis. The control of ethylene biosynthesis by OsDOF15 in turn regulates cell proliferation in the root meristem. OsDOF15 transcription is repressed by salt stress, and OsDOF15‐mediated ethylene biosynthesis plays a role in inhibition of primary root elongation by salt stress. Thus, our data reveal how the ethylene‐inhibited primary root elongation is finely controlled by OsDOF15 in response to environmental signal, a novel mechanism of plants responding to salt stress and transmitting the information to ethylene biosynthesis to restrict root elongation.

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Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase

Cited by 80 publications

References 73 publications

Promotion of Flower Opening of Spray-type Carnation Cut Flowers by 3-Pyridinecarboxylic Acid, a Simple Analog of Pyridinedicarboxylic Acids (PDCAs) Including 2,3- and 2,4-PDCAs

Promotion of Flower Opening of Spray-type Carnation Cut Flowers by 3-Pyridinecarboxylic Acid, a Simple Analog of Pyridinedicarboxylic Acids (PDCAs) Including 2,3- and 2,4-PDCAs

Phosphoethanolamine N‐methyltransferase 1 contributes to maintenance of root apical meristem by affecting ROS and auxin‐regulated cell differentiation in Arabidopsis

Rice OsDOF15 contributes to ethylene‐inhibited primary root elongation under salt stress

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