Pyrazolo[3,4-d]pyrimidine ribonucleosides as anticoccidials. 2. Synthesis and activity of some nucleosides of 4-(alkylamino)-1H-pyrazolo[3,4-d]pyrimidines

Abstract

Pyrazolo [3,4-d]pyrimidine Ribonucleosides as Anticoccidials. 2. Synthesis and Activity of Some Nucleosides of 4-(Alkylamino)-lff-pyrazolo [3,4-d]pyrimidines

Nucleoside Synthesis Mediated by Glycosyl Transferring Enzymes

“…Sometimes, the released nucleobase from the glycosyl donor binds more strongly with the enzyme than the acceptor base, which results in competitive inhibition (26). The problem of inhibition can be solved by using a coupled enzymatic system, e.g., pyrimidine and purine nucleoside phosphorylase together with a pyrimidine nucleoside as the glycosyl SCHEME 1 donor and a purine base as the acceptor, since the released pyrimidine base does not inhibit the purine nucleoside phosphorylase (Scheme 3) (27)(28)(29)(30).…”

Crystal structure of N,N-dimethyl-N′-(2-methyl-4-oxo-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)formimidamide, C14H18N4OS

“…agents is limited due to the rapidly developing drug resistance in conjunction with the unsatisfactory status of present treatments of bacterial and fungal infections [3,4]. Pyrimidine nucleus has gained potential importance in medicinal chemistry, as some of its derivatives exhibited a wide range of biological activities, such as antiviral [5][6][7][8], anticoccidials [9,10], antimicrobial [11][12][13][14], antitumor [15][16][17][18], herbicidal, antileukemic [19,20], pesticides [21], CNS agents [22], tuberculostatic [23][24][25], antileishmanial [26][27][28], radioprotectant [29], anti-in ammatory [30], and cardiovascular activities [31,32]. The biological signicance of the above heterocycle prompted us to explore the synthesis of novel pyrimidines from 3-amino-2-methyl-5,6, 7,8-tetrahydrobenzo [4,5] The asymmetric unit of the title compound contains one independent molecule.…”

Synthesis and in vitro antiproliferative activity of novel pyrazolo[3,4-d]pyrimidine derivatives

“…Pyrazoloij3,4-d]pyrimidine derivatives demonstrate various biological activities, such as inhibition of phosphodiesterase-5 (PDE-5), 5 modulation of the human adenosine receptor, 6 antiviral, 7 anticoccidial, 8 antimicrobial, 9 etc. These investigations revealed that substitution of various groups on the ring imparts different activities.…”