Pyrazolo-benzothiazole hybrids: Synthesis, anticancer properties and evaluation of antiangiogenic activity using in vitro VEGFR-2 kinase and in vivo transgenic zebrafish model

Self-assembled and pH-responsive polymeric nanomicelles impart effective delivery of paclitaxel to cancer cells

“…This was carried out due to the close resemblance of the three-dimensional spheroid system with that of the tumor microenvironment, thus mimicking the cytotoxicity and activity of the anti-cancer reagents in the real tumour environments. 60,61 The IC 50 of the PTX formulations were assessed by their addition on the cells for 72 h and the cells were further stained using the live/dead staining kit which selectively stained the live and dead cells in green and red colours, respectively. In contrast to the data obtained in the 2D assay, the live dead staining showed prominent cell death in the cells treated with NM-2 while NM-1 and pure PTX treated cells displayed signicantly less cell death (Fig.…”

Design and synthesis of thiadiazolo-carboxamide bridged β-carboline-indole hybrids: DNA intercalative topo-IIα inhibition with promising antiproliferative activity

“…This assay is based on the ability of the healing of an artificial wound called “scratch” created using a sterile pipette tip (200 μL). [45] , (a) , (b) The cells were treated with a range of concentrations varying from 1.25 to 5 μM of 12c , along with control, and images were captured at 0 and 72 h and compared. It is inferred from Fig.…”

Design, synthesis, docking, ADMET profile, and anticancer evaluations of novel thiazolidine‐2,4‐dione derivatives as VEGFR‐2 inhibitors

“…Depending on ligand‐based drug design, especially a molecular hybridization approach that involves the coupling of two or more groups with relevant biological properties, [ 31–33 ] molecular hybridization of 5‐[(4‐chloro/2,4‐dichloro)benzylidene]thiazolidine‐2,4‐diones and other effective antitumor moieties was carried out in an attempt to obtain new molecules with potent antitumor activity.…”