Pyrene drives reduced brain size during early life exposure in an estuarine fish, the red drum (Sciaenops ocellatus)

Khursigara, Alexis J.; Ackerly, Kerri Lynn; Esbaugh, Andrew J.

doi:10.1016/j.cbpc.2022.109397

Cited by 5 publications

(1 citation statement)

References 48 publications

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“…Анализ экспрессии генов показал, что ПАУ вызывают снижение экспрессии нескольких белков, ответственных за транспорт нейромедиаторов и метаболитов, в том числе серотонина и норадреналина, а также нарушают кальциевый сигналинг в нейронах, что может иметь более глубокие последствия -например, влиять на синаптическую пластичность, процессы запоминания и обучения [79]. У красного горбыля (Sciaenops ocellatus) воздействие ПАУ на ранних этапах развития приводит к уменьшению размеров головного мозга, уменьшению числа нейронов и нарушению развития и функционирования синапсов [80,81]. В периферической нервной системе ПАУ также вызывают изменения структуры и функции: помимо упомянутого выше нарушения развития глазных яблок (микрофтальм), ПАУ и сырая нефть вызывают апоптоз клеток сетчатки и уменьшение числа синапсов.…”

Section: влияние пау на нервную систему рыбunclassified

Physiological effects of polycyclic aromatic hydrocarbons (PAH) in fish organism

Filatova,

Abramochkin

2023

Vestn. Mosk. Univ. Ser. 16. Biol.

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The pollution of world ocean is a serious threat to the biodiversity of flora and fauna. One of the most important sources of pollution are oil and oil products – every year more than 1 million tons of oil is spilled into the sea as a result of accidents during oil production or transportation. The teratogenic and carcinogenic effects of such oil components as benzopyrene is well known since the middle of the last century. However, after a large oil spill from “Exxon Valdez” tanker in 1989 it became clear that oil and its components have strong toxic effects in fish organism – and to a large extent these effects are caused by di- and tricyclic aromatic hydrocarbons, in particular phenanthrene. Field research have demonstrated that fish embryo and larvae are the most prone to the effects of oil – and the largest oil spills endanger the populations of important commercial fish species that spawn in this area. This review considers the influence of polycyclic aromatic hydrocarbons (PAH) on the physiology of various organ systems in fish. Particular attention is paid to the cardiotoxic effects of PAH which were recently discovered and which are potentially not only the main cause of animals’ death upon the spill of PAH into water, but also underlie the malformation of other organs.

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Section: влияние пау на нервную систему рыбunclassified

Physiological effects of polycyclic aromatic hydrocarbons (PAH) in fish organism

Filatova,

Abramochkin

2023

Vestn. Mosk. Univ. Ser. 16. Biol.

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Reduced pigmentation and thyroid hormone disruption in zebrafish embryos caused by industrial sludge near Bohai Bay, China

Dong

Yin

et al. 2023

Water Biology and Security

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Neurotoxic Effects of Polycyclic Aromatic Hydrocarbons in Vertebrates, from Behavioral to Cellular Levels

Dunton

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Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental toxicants found in anthropogenic mixtures such as crude oil, air pollution, vehicle exhaust, and in some natural combustion reactions. Single PAHs such as benzo[a]pyrene (BaP) also impact fish behavior when animals are exposed in early life stages and for short periods of time. Aquatic animals such as fish may encounter BaP through road runoff and oil spills, but few studies have examined the impact of aqueous exposure on adult fish, and fewer have examined the resulting fitness-relevant behavioral consequences of BaP and PAH mixtures and their long-term persistence. This dissertation targets this gap in the literature by examining how aqueous exposure to BaP influences anxiety-like behavior, learning, and memory in adult zebrafish, and how parental exposure to the PAH mixture, crude oil, combined with hypoxia affects social and exploratory behavior in unexposed larval zebrafish. We found that learning and memory were not affected by 24 hour exposure to BaP, that anxiety-like behavior was minimally affected, and that locomotor parameters such as distance moved and times spent in darting and immobile states were significantly altered by exposure to BaP. Additionally, we found that parental exposure to crude oil and hypoxia decreased larval velocity. Additionally, we examined how crude oil, BaP, and the detergent COREXIT influence a monolayer of mouse and fish endothelial cells, as an in vitro blood-brain barrier (BBB) model. We found that exposure to BaP in particular caused significant damage to both fish and mammal in vitro BBB models, and damage to the BBB is one potential mechanism by which neural integrity and behavior may be influenced. Understanding how these toxicants influence fish brains and behavior will give insight into how fish populations explore and interact with their environment and with predators, and how these interactions persist even when toxicants are no longer present.

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Pyrene drives reduced brain size during early life exposure in an estuarine fish, the red drum (Sciaenops ocellatus)

Cited by 5 publications

References 48 publications

Physiological effects of polycyclic aromatic hydrocarbons (PAH) in fish organism

Physiological effects of polycyclic aromatic hydrocarbons (PAH) in fish organism

Reduced pigmentation and thyroid hormone disruption in zebrafish embryos caused by industrial sludge near Bohai Bay, China

Neurotoxic Effects of Polycyclic Aromatic Hydrocarbons in Vertebrates, from Behavioral to Cellular Levels

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