Pyrethroid insecticides influence the signal transduction in T helper lymphocytes from atopic and nonatopic subjects

Diel, F.; Horr, B.; Borck, H.; Irman-Florjanc, T.

doi:10.1007/s000110300066

Cited by 36 publications

(37 citation statements)

References 36 publications

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“…That would partially lead to the inhibition of cell viability. A previous study suggested that SPs inhibited signal transduction in human lymphocytes ex vivo [11], and the present results further demonstrated that the common SP metabolites can also inhibit signal pathways in human monocytes and may induce immune dysfunctions.…”

supporting

confidence: 53%

“…The popularity of SPs is attributed to their high efficacy to insects, low environmental mobility, and relatively low mammalian and avian toxicity [7]. However, an increasing number of studies show that SPs are capable of disrupting hormonal activities [8], causing oxidative stress [9], inducing immune suppression [10], and inhibiting signal transduction [11]. Pyrethroids are metabolized oxidatively and hydrolytically to form a number of primary and secondary metabolites [12].…”

Section: Introductionmentioning

confidence: 99%

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Immunotoxicity of pyrethroid metabolites in an in vitro model

Zhang

Zhao

Jin

et al. 2010

Enviro Toxic and Chemistry

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Risk assessment of man-made chemicals such as pesticides are mainly focused on parent compounds, and relatively little is known about their metabolites, especially with regard to target organ damages such as immunotoxicity. In the present study, the immunotoxicity of five synthetic pyrethroids (SPs) and three common metabolites was evaluated using an in vitro model by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, cytoflow, and enzyme-linked immunosorbent assay (ELISA). Cell viability and apoptosis assays showed that both SPs and their metabolites possessed cytotoxicity to the monocytic cells. The aldehyde and acid derivatives were more effective than the other compounds at cytotoxicity, with inhibition of cell viability by 56.8 and 50.6% at 10⁻⁵ mol L⁻¹, and induction of 8.52 and 8.81% cell apoptosis, respectively. Exposure to SPs and their metabolites also led to changes in the secretion levels of tumor necrosis factor α (TNF α) and interleukins (ILs), and again the metabolites showed stronger effects than the parent compounds. The aldehyde derivative upregulated IL-12p70 level by 1.87-fold, and the alcohol and acid derivative increased the secretion of TNF α 5.88 and 7.96-fold, relative to the control group. In the in vitro model, the common metabolites of SPs clearly exerted greater immunotoxic effects to monocytes than the intact parent compounds. Results from the present study suggested the need for considering metabolites in achieving more comprehensive health risk assessment of man-made chemicals, including target organ toxicities such as immunotoxicity.

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supporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Immunotoxicity of pyrethroid metabolites in an in vitro model

Zhang

Zhao

Jin

et al. 2010

Enviro Toxic and Chemistry

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“…Its low sensitivity in mammals ensures low acute toxicity. Recently, animal and in vitro studies suggest that some PYRs may disrupt the immune function, 50,51) produce oxidative stress, [52][53][54][55] and possess male reproductive toxicity by disrupting testosterone biosynthesis due to diminishing the delivery of cholesterol into the mitochondria and the conversion of cholesterol to pregnenolone in Leydig cells. 56) Moreover, it has been reported that the PYR metabolites, 3-PBAlc and 3-PBAld, possess estrogenic activity of approximately 10 5 less than that of 17b -estradiol.…”

Section: Results Unitsmentioning

confidence: 99%

Analysis and evaluation of pyrethroid exposure in human population based on biological monitoring of urinary pyrethroid metabolites

2010

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The current risk assessment of human exposure to low-level pyrethroids (PYRs) is generally based on the estimation of residue intake from diets. Limited data are available on individual exposure levels in human studies, which is partly attributable to the difficulty in biological monitoring of PYR exposure. This obstacle has been overcome in recent years due to the evolution of analytical chemistry. Separation and sensitive identification and quantitation of urinary PYR metabolites are today reliably made with liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry. This article gives an overview of the biological monitoring of urinary PYR metabolites, reviews PYR metabolite levels in general populations, and discusses future research perspectives in the field of environmental health.

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“…These insecticides, synthetic analogues of natural pyrethrins, act through intestinal contact, thereby affecting the nervous and the immune systems (22)(23)(24). With pyrethroid, the values of EC 80 are smaller for the bacterial system than for the coupled enzymatic system.…”

Section: Resultsmentioning

confidence: 96%

A bioluminescent signal system: detection of chemical toxicants in water

Vetrova

Esimbekova

Remmel³

et al. 2007

Luminescence

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Prototype technologies of a bioluminescent signal system (BSS) based on the luminous bacterium Photobacterium phosphoreum and three enzymatic bioluminescence systems have been proposed for detecting and signalling the presence of toxicants in water systems. A number of pesticides, mostly known as poisonous substances, similar in their structures and physicochemical properties, have been taken as model compounds of chemical agents. The effect of toxicants (organophosphates, derivatives of dithiocarbamide acid, and pyrethroid preparations) on the bioluminescence of the four systems has been analysed. EC(50) and EC(80) have been determined and compared to the maximum permissible concentration for each of the analysed substances. The triple-enzyme systems with ADH and trypsin have been shown to be more sensitive to organophosphorous compounds (0.13-11 mg/L), while the triple-enzyme system with trypsin is highly sensitive to lipotropic poison, a derivative of dithiocarbamine acid (0.03 mg/L). Sensitivities of the triple-enzyme systems to pyrethroid preparations are similar to those of luminous bacteria (0.9-5 mg/L). The results can be used to construct an alarm-test bioluminescence system for detecting chemical toxicants, based on intact bacteria or enzyme systems.

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Pyrethroid insecticides influence the signal transduction in T helper lymphocytes from atopic and nonatopic subjects

Abstract: It can be suggested that pyrethroids inhibit signal transduction in human lymphocytes ex vivo, and do not act via lymphocyte-influencing histamine release.

Cited by 36 publications

References 36 publications

Immunotoxicity of pyrethroid metabolites in an in vitro model

Immunotoxicity of pyrethroid metabolites in an in vitro model

Analysis and evaluation of pyrethroid exposure in human population based on biological monitoring of urinary pyrethroid metabolites

A bioluminescent signal system: detection of chemical toxicants in water

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