Pyrexia/Pruritus/haemorrhagic syndrome in dairy cows

Matthews, John G.; Shreeve, B.J.

doi:10.1136/vr.103.18.408

Cited by 13 publications

(13 citation statements)

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“…Um exame mais acurado na literatura mais remota revela que enfermidades semelhantes têm sido descritas, sem suspeita da causa (Breukink et al 1978, Matthews & Shreeve 1978 ou atribuídas a micotoxicoses (Albright et al 1964, Petrie 1977, infecção por fungo (Andrews et al 1983), infecção geral (Turner et al 1978), processos alérgicos e até ingestão de silagem (Thomas 1978, 1979, Holden 1980. Saunders et al (2000), aparentemente estudando o mesmo surto de mortandade em bovinos investigado por Pollak et al (1998), em que foi levantada a suspeita de ter sido causada pela alimentação com polpa cítrica, dizem que o princípio tóxico é desconhecido, mas como na intoxicação pela ervilhaca, o caráter da inflamação nos órgãos sugere reação de hipersensibilidade do tipo IV; a lectina estaria atuando como imuno-estimulante.…”

Section: Introdução Introduçãounclassified

Experimentos com a polpa cítrica em ovinos e coelhos

2001

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Citrus pulp was fed to sheep and rabbits in high doses and during long periods, in order to find an experimental model. The citrus pulp used in the experiments in sheep was the same used by a cattle breeder in Lorena, State of São Paulo, who lost out of a total of 56 lactating cows during a period of a few weeks 5 animals by a disease characterized histologically by granulomatous lesions. The 4 sheep used in the experiments received 800g/day/animal of this citrus pulp during 10 to 11 months. They were euthanized at the end of the experiment. None of the sheep showed the clinical-pathological picture of citrus pulp poisoning seen in cattle or other alterations. In the experiments in rabbits citrus pulp of two procedures were used. In one series (6 rabbits) the same citrus pulp was given as used in the experiments in sheep; in the other series (6 rabbits) the citrus pulp used in experiments in dogs, in which it caused granulomatous lesions, was given. The rabbits of the first series ingested an average of 51.5 g/day/animal; the rabbits of the second series ingested an average of 35.2 g/kg/animal of the citrus pulp. The rabbits were euthanized 2, 3, 6 and 12 months after the beginning of the experiments. None of the rabbits showed the clinical and pathological picture of citrus pulp poisoning or any other alterations.INDEX TERMS: Experimental citrus pulp poisoning, sheep, rabbits.

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Section: Introdução Introduçãounclassified

Experimentos com a polpa cítrica em ovinos e coelhos

2001

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“…1 None of the approximately cytic/plasmacytic/eosinophilic/multinucleated giant 50 cattle that developed the syndrome in 1978 in Britcell infiltration causing enlargement and architectural ain received DUIB. 10 disruption of the many infiltrated organs. Grossly, the An attempt to induce the vetch-associated syndrome infiltrates are gray to gray-yellow, moderately firm, and by enforced grazing of 3 cattle on a pure stand of hairy when not confluent, sharply demarcated from adjacent vetch for 28 days did not result in disease.…”

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“…Red urine has been reported in a few were reported in the late 1970s. 7,10,16 Concurrently, a animals. Sporadic abortion has been reported by cattle similar syndrome in the Netherlands was associated owners.…”

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Hairy Vetch (Vicia VillosaRoth) Poisoning in Cattle: Update and Experimental Induction of Disease

1992

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Abstract. Hairy vetch poisoning (vetch-associated disease) of cattle is a generalized disease characterized pathologically by infiltration of skin and many internal organs by monocytes, lymphocytes, plasma cells, and often eosinophils and multinucleated giant cells and clinically by dermatitis, pruritis, often diarrhea, wasting, and high mortality. The disease was experimentally reproduced in an adult Angus female that had recovered from the natural disease 1 year earlier. She developed dermatitis on the 11th day of vetch feeding, and despite withdrawal from the vetch diet on the 12th day, death occurred 24 days after first day of vetch feeding. The cow developed lymphocytosis and hyperproteinemia. The results of other hematologic evaluations, blood chemical profiles, urinalysis, and cutaneous hypersensitivity tests using vetch lectin were normal. Lymphocyte blastogenesis studies with vetch lectin were not interpretable. Necropsy revealed gross lesions characteristic of the disease in the skin, heart, kidney, adrenal, and lymphoid tissues. Microscopically there was typical cellular infiltration in those organs and in the thyroid, liver, pancreas, salivary and mammary glands, urinary bladder, corpus luteum, and cerebral meninges. Cutaneous apocrine gland necrosis was present. The inflammatory reaction has qualities of a type-IV hypersensitivity reaction. Hypersensitivity may occur when constituents of the ingested plant are absorbed and act as antigens that sensitize lymphocytes and evoke the multisystemic granulomatous inflammatory response that characterizes the disease. Alternatively, vetch lectin may directly activate T lymphocytes to initiate the cellular response. Vetch-like diseases have been associated with a variety of diets that did not contain hairy vetch. The gross and histopathologic lesions of the vetch-associated and the vetch-like diseases are not mimicked in quality and distribution by any other disease.

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“…Essas doenças são clínica e histologicamente muito semelhantes à intoxicação por ervilhaca e ocorrem principalmente em vacas de leite recebendo silagem ou concentrado durante o inverno. Dentre essas, se inclui uma doença descrita no Reino Unido e associada ao consumo, pelos bovinos, de silagem contendo o conservante químico comercial Sylade (Matthews & Shreeve 1978, Thomas 1978, Turner et al 1978, Thomas 1979, uma combinação de formalina com ácido sulfúrico, e de feno contendo aditivo (Andrews et al 1983). Uma outra doença semelhante à intoxicação por ervilhaca foi descrita na Holanda em bovinos que recebiam ração contendo diuriedo-isobutano (DUIB) (Breukink et al 1978).…”

Section: Achados Histopatológicos Achados Histopatológicosunclassified

“…No entanto, a reprodução experimental é difícil e só foi conseguida uma única vez em uma vaca de 7 anos e 432 kg que havia se recuperado da intoxicação espontânea um ano antes e que consumiu um total de 100 kg de ervilhaca. A grande maioria dos casos de doença granulomatosa sistêmica por ervilhaca em bovinos está associada ao pastoreio de V. villosa (Quadro 1); na África do Sul a doença foi associada ao pastoreio de um híbrido, cruza de V. villosa com V. dasycarpa (Burroughs et al 1983) (Matthews & Shreeve 1978). Além disso, todas essas doenças tendem a ocorrer em animais de certas faixas etárias (mais em adultos) e de certas raças.…”

Section: Discus Discussão Sãounclassified