Pyridaben induced cardiotoxicity during the looping stages of zebrafish (Danio rerio) embryos

Ma, Jinze; Huang, Yong; Ping, Jiang; Liu, Zhou; Luo, Qiang; Zhong, Keyuan; Yuan, Wei; Meng, Yunlong; Lu, Huiqiang

doi:10.1016/j.aquatox.2021.105870

Cited by 28 publications

(19 citation statements)

References 53 publications

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“…Exposure to pyridaben can induce embryonic loss in early pregnancy in pigs ( Bae et al, 2021 ). Pyridaben is highly toxic to aquatic organisms, such as shrimp ( Mysidopsis bahia ), bluegill sunfish ( Lepornis macrochirus ), rainbow trout ( Oncorhynchus mykiss ), and zebrafish ( Danio rerio ) ( Rand and Clark, 2000 ; European Food Safety Authority, 2010 ; Ma et al, 2021a ). For nontarget arthropods such as honey bees and predatory mites, the hazard quotient values of pyridaben were significantly above the trigger values ( European Food Safety Authority, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

An overview on the green synthesis and removal methods of pyridaben

Chen

Pan

2022

Front. Chem.

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Pyridaben is an acaricide widely used around the world to control phytophagous mites, white flies, aphids, and thrips. It is highly toxic to nontarget organisms such as predatory mites, bees, and fishes. Therefore, the occurrence and removal of pyridaben in food and the environment are worthy of concern. This mini-review focuses on pyridaben residue levels in crops, aquatic systems, and soils, as well as the green synthesis and removal of pyridaben. During the period of 2010–2022, pyridaben was reported in monitoring studies on fruits, vegetables, herbs, bee products, aquatic systems, and soils. Vegetable and agricultural soil samples exhibited the highest detection rates and residue levels. One-pot synthesis offers a green chemistry and sustainable alternative for the synthesis of pyridaben. Among traditional home treatments, peeling is the most effective way to remove pyridaben from crops. Magnetic solid-phase extraction technology has emerged as a powerful tool for the adsorption and separation of pyridaben. Photocatalytic methods using TiO2 as a catalyst were developed as advanced oxidation processes for the degradation of pyridaben in aqueous solutions. Current gaps in pyridaben removal were proposed to provide future development directions for minimizing the exposure risk of pyridaben residues to human and nontarget organisms.

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Section: Introductionmentioning

confidence: 99%

An overview on the green synthesis and removal methods of pyridaben

Chen

Pan

2022

Front. Chem.

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“…S1 † ) is a pyridazinone broad-spectrum acaricide developed by Nissan Chemical Industries Ltd in 1985. 1 Because of its low application dosage and quick effect, pyridaben has become the most widely used acaricide on citrus trees, apple trees, and cabbage to control pests ( e.g. , red spider and yellow striped beetle).…”

Section: Introductionmentioning

confidence: 99%

“…11 Ma et al showed that pyridaben can cause severe cardiac malformations, functional abnormalities, and disrupts heart development gene expression in zebrafish. 1 Therefore, the fate of pyridaben in aqueous solutions must be understood to evaluate its potential hazard for aquatic ecosystems.…”

Section: Introductionmentioning

confidence: 99%

“…S1 †) is a pyridazinone broadspectrum acaricide developed by Nissan Chemical Industries Ltd in 1985. 1 Because of its low application dosage and quick effect, pyridaben has become the most widely used acaricide on citrus trees, apple trees, and cabbage to control pests (e.g., red spider and yellow striped beetle). [1][2][3][4] It acts mainly by inhibiting the synthesis of glutamate dehydrogenase in the chromosomes of the muscle tissue, nerve tissue, and electron transport systems.…”

Section: Introductionmentioning

confidence: 99%

“…1 Because of its low application dosage and quick effect, pyridaben has become the most widely used acaricide on citrus trees, apple trees, and cabbage to control pests (e.g., red spider and yellow striped beetle). [1][2][3][4] It acts mainly by inhibiting the synthesis of glutamate dehydrogenase in the chromosomes of the muscle tissue, nerve tissue, and electron transport systems. 5,6 Pyridaben is the main ingredient of many commercial pesticide products on the agrochemical market.…”

Section: Introductionmentioning

confidence: 99%

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Kinetics of the photolysis of pyridaben and its main photoproduct in aqueous environments under simulated solar irradiation

Pan

et al. 2022

RSC Adv.

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Oxidative stress contributes to flumioxazin‐induced cardiotoxicity in zebrafish embryos

Ma,

Jiang,

Huang

et al. 2023

Enviro Toxic and Chemistry

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Flumioxazin is a widely applicated herbicide in the control of aquatic plants. Current evidence suggested that flumioxazin could induce cardiac defects (ventricular septal defects) in vertebrates, but the underlining mechanisms remain unclear. Because of the inhibitory effect of flumioxazin on polyphenol oxidase (PPO), the assumption is made that flumioxazin‐induced cardiotoxicity is caused by oxidative stress. The results show that flumioxazin induced cardiac malformations and abnormal gene expression associated with cardiac development. Cardiac malformations include pericardium edema, cardiac linearization, elongated heart, cardiomegaly, cardiac wall hypocellularity, myocardial cell atrophy into granular, and a significant gap between the myocardial intima and the adventitia. An increase in oxidative stress and apoptosis was observed in the cardiac region of zebrafish after exposure to flumioxazin. Antioxidant astaxanthin reversed the cardiac malformations, excessive ROS production and expression of genes for cardiac developmental and apoptosis regulation induced by flumioxazin. In addition, flumioxazin also activated AHR signaling pathway genes (ahr2, cyp1a1, and cyp1b1) and increased porphyrins concentration. In conclusion, the results suggest that excessive ROS production, which could be mediated through AHR, led to apoptosis, contributing to the cardiotoxicity of flumioxazin in zebrafish embryos.

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Pyridaben induced cardiotoxicity during the looping stages of zebrafish (Danio rerio) embryos

Cited by 28 publications

References 53 publications

An overview on the green synthesis and removal methods of pyridaben

An overview on the green synthesis and removal methods of pyridaben

Kinetics of the photolysis of pyridaben and its main photoproduct in aqueous environments under simulated solar irradiation

Oxidative stress contributes to flumioxazin‐induced cardiotoxicity in zebrafish embryos

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