Pyridazine derivatives and related compounds. Part 13: Synthesis and antimicrobial activity of some pyridazino[3′,4′:3,4]pyrazolo[5,1-c]-1,2,4-triazines

Synthesis and antibacterial activity of some new thiadiaza/triazaphospholes, thiadiaza/triaza/tetrazaphosphinines and thiadiaza/tetrazaphosphepines containing 1,2,4-triazinone moiety

“…6-Methyl-2-oxido-2-phenyl-1,2-dihydro-7H- [1,3,4,2]thiadiazaphospholo [5,4-c] [1,2,4]triazin-5-one (2) was synthesized by the reaction of 4-amino-3-mercapto-6-methyl-1,2,4-triazin-5(4H)-one (1) with phenylphosphonic dichloride in THF containing 2 equiv amounts of triethylamine to remove hydrogen chloride (Scheme 1). The molecular structure of 2 was deduced from its IR spectrum, which showed the absorption bands of NH, C]O and P]O groups at 3158, 1681 and 1225 cm À1 , respectively.…”

“…Various substituted 1,2,4-triazin-5-one derivatives have a great importance as biological agents in medicinal and agricultural fields [1][2][3][4][5]. Recently, significant activities have been directed toward this class of compounds, in particular, 4-amino-1,2,4-triazin-5(2H)-one derivatives which have considerable interest because of their herbicidal [6,7], antimicrobial [8][9][10], anti-HIV [11] and anticancer activities [12,13].…”

Synthesis, crystal structures and properties of the novel mononuclear copper(II) and tetranuclear cobalt(II) complexes with 3,6-bis-(3,5-dimethylpyrazolyl)-pyridazine

“…In most cases, bridging azide groups take end-to-end (EE, l-1,3) and end-on (EO, l-1,1) coordination modes. The pyridazine and it's derivatives as the functional ligands have shown much useful function, such as application in magnetic exchange effects [4][5][6][7][8][9], pharmaceutical importance [10][11][12] and antimicrobial [13][14][15]. 3,6-bis-(3,5-dimethylpyrazolyl)-pyridazine (L) is one of the pyridazine derivatives, which as a function ligand has shown versatile properties in respect of the formation of monouclear and polynuclear complexes due to the formation of the five-membered metallacycles stabilizing the configurations around the metal center [16].…”

1,2,4-Triazine Chemistry Part II: Synthetic approaches for phosphorus containing 1,2,4-triazine derivatives

“…Various substituted 1,2,4-triazine derivatives have a great importance as biological agents in medicinal and agricultural fields [1][2][3][4][5][6]. Recently, this class of compounds have gained considerable interest because of their herbicidal [7,8], antimicrobial [9][10][11], anti-HIV [12] and anticancer activities [13,14].…”