Pyridazinones: A versatile scaffold in the development of potential target‐based novel anticancer agents

Abstract

Pyridazinones are important nitrogen-rich heterocyclic core that has been driving the substantial medicinal interest due to their wide range of biological activities. This privileged scaffold forms a central core in numerous potent compounds, which results in the development of novel anticancer drugs with fruitful biological activities. The current review article summarizes the progressive development of novel pyridazinone derivatives that are targets for numerous receptors such as C-met kinase inhibitors, PARP inhibitors, Tubulin polymerization inhibitors, Dihydro folate reductase inhibitors, B-Raf inhibitors, Bruton tyrosine kinase inhibitors, FER tyrosine kinase inhibitors, and fibroblast growth factors receptors. It features the various simple techniques for the synthesis of pyridazinones and also highlights the mechanistic insights into the anticancer properties of pyridazinone derivatives.

Synthesis, Characterization and Cytotoxic Evaluation of New Pyrrolo[1,2-b]pyridazines Obtained via Mesoionic Oxazolo-Pyridazinones

“…The cycloaddition reactions of the mesoionic münchnones is a chosen method in the synthesis of the compounds from these classes, this procedure has been applied by Dumitrascu et al [32,33] for a new synthesis of pyrrolo [1,2-b]pyridazine derivatives, starting from 3(2H)pyridazinone acids. The pyridazinone skeleton is also present in many compounds with significant biological activities including anticancer, antiinflammatory, analgesic, antimicrobial, antidiabetic, anticonvulsant, anxiolytic, antidepressant, antihypertensive [7,8,[34][35][36][37], and optical properties [38,39]. The interest in heterocyclic condensed systems with bridgehead nitrogen from pyrroloazines class has been growing for several decades, both for the versatility of their chemistry and especially for their pharmaceutical potential.…”

Exploring Three Avenues: Chemo- and Regioselective Transformations of 1,2,4-Triketone Analogs into Pyrazoles and Pyridazinones

“…At the same time, pyridazine derivatives have attracted extensive attention due to their broad spectrum of biological activity, which has found use in therapeutic agents for the treatment of vasoconstriction (levosimendan [ 26 ]), allergies (azelastine [ 27 ]), cancer (olaparib [ 28 ]), and depression (minaprine [ 29 ]). In particular, pyridazinone scaffold is considered crucial for the discovery of drugs [ 11 , 14 , 30 , 31 , 32 , 33 , 34 , 35 ].…”