Pyridine alkaloids with activity in the central nervous system

Lin, Simon X.; Curtis, Maurice A.; Sperry, Jonathan

doi:10.1016/j.bmc.2020.115820

Cited by 69 publications

(42 citation statements)

References 180 publications

(572 reference statements)

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“…9,10 In plants, they are mostly found in the alkaloids. 11 In biological systems, redox reactions of nicotinamide adenine dinucleotide (NAD) reduces its pyridine ring into dihydropyridine, rendering NADH. Similar redox reactions are also present in anabolic reactions involving NAD phosphate (NADP + /NADPH) interconversion.…”

Section: Introductionmentioning

confidence: 99%

The Expanding Role of Pyridine and Dihydropyridine Scaffolds in Drug Design

Ling

Hao

Liang

et al. 2021

DDDT

216

114

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Pyridine-based ring systems are one of the most extensively used heterocycles in the field of drug design, primarily due to their profound effect on pharmacological activity, which has led to the discovery of numerous broad-spectrum therapeutic agents. In the US FDA database, there are 95 approved pharmaceuticals that stem from pyridine or dihydropyridine, including isoniazid and ethionamide (tuberculosis), delavirdine (HIV/AIDS), abiraterone acetate (prostate cancer), tacrine (Alzheimer's), ciclopirox (ringworm and athlete's foot), crizotinib (cancer), nifedipine (Raynaud's syndrome and premature birth), piroxicam (NSAID for arthritis), nilvadipine (hypertension), roflumilast (COPD), pyridostigmine (myasthenia gravis), and many more. Their remarkable therapeutic applications have encouraged researchers to prepare a larger number of biologically active compounds decorated with pyridine or dihydropyridine, expandeing the scope of finding a cure for other ailments. It is thus anticipated that myriad new pharmaceuticals containing the two heterocycles will be available in the forthcoming decade. This review examines the prospects of highly potent bioactive molecules to emphasize the advantages of using pyridine and dihydropyridine in drug design. We cover the most recent developments from 2010 to date, highlighting the ever-expanding role of both scaffolds in the field of medicinal chemistry and drug development.

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Section: Introductionmentioning

confidence: 99%

The Expanding Role of Pyridine and Dihydropyridine Scaffolds in Drug Design

Ling

Hao

Liang

et al. 2021

DDDT

216

114

View full text Add to dashboard Cite

show abstract

“…These compounds comprise mixtures of volatile, complex hydroalcoholic oil-soluble compounds, which are used as cosmetics and pharmaceuticals. Their structures are as follows: Acyclic and monocyclic monoterpenes (1,8-cineole, alfa pinene, camphor, linalool, nerol, and geraniol), bicyclic and tricyclic monoterpenes (sabinene, thujone, and tricyclene), sesquiterpenes (e-nerolidol, carvacrol methyl ether, germacrene B, and cadalene), isoprenoides, and terpenoids that include aldehydes, ethers, alcohols (carvacrol, thymol, eugenol, and borneol), and sulfur- or nitrogen-containing compounds (diallyl disulfide and indole) [ 84 , 85 ]. Mentions of essential oil plants, essential oils, and their derived single constituents appear in pharmacopoeias and traditional medicine paradigms of different cultures.…”

Section: Plants Used In Traditional (Folk) Medicine In Latviamentioning

confidence: 99%

Traditional Latvian herbal medicinal plants used to treat parasite infections of small ruminants: A review

et al. 2021

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Numerous treatment agents offering prophylaxis against livestock parasites are commercially available. However, because of increasing antiparasitic drug resistance, the increased popularity of environmentally friendly lifestyle choices, and organic farming, there is more demand for new alternatives to livestock anthelmintic control strategies and medications. It is important to develop antiparasitics that are safe, effective, inexpensive, and environmentally safe. Local, traditional herbal plants such as tansy, mugwort, wormwood, and heather may serve as treatments for intestinal parasites of sheep. This overview provides knowledge of traditional Latvian plants with antiparasitic activities to establish a database for further research to develop new herbal antiparasitic drugs.

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“…The cooled reaction mixture was stirred for 30 min, then reaction was brought to room temperature and stirred for further one hour. The reaction mixture was 8,127.6,122.4,118.4, 7,133.8,127.4,121.4,118.4, 4,129.2,127.4,123.5,121.4,119.2,118.4, 5,158.2,148.0,141.3,137.0,136.7,133.8,130.4,127.4,123.6,121.4,118.4,116.3…”

Section: Synthesis Of Boc Tryptophan (2)mentioning

confidence: 99%

“…During the last two decades, numerous kinds of alkaloids were isolated from the natural sources and studied their importance in biological and pharmaceutical applications [3,4]. Clinically natural alkaloids are famous to treat central nervous system (CNS) disorders for instance atropine, physostigmine morphine, anatabine and papaverine etc [5]. Studies have revealed that wide range of natural alkaloids are biologically active molecules and have been using to treat many pathogenic diseases [6].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of β-carboline fatty alcohol hybrids as potential biological active and antioxidant molecules

Kontham¹,

Ippakayala²,

Madhu³

2020

Preprint

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Nine new β-carboline fatty alcohol hybrids were synthesized from natural amino acid L-tryptophan and hybridized with 10-undecenol via ester linkage. All the synthesized products were characterized in each step by spectral techniques (1H, 13C NMR mass and HRMS). Synthesized β-carboline derivatives (7a-i) were screened for biological activities such as antimicrobial, antifungal, antibio film and anticancer. Compounds 7d and 7f showed most potent antimicrobial activity against B.subtilis MTCC 121, M.luteus MTCC 2470, S.aureus MTCC 96 and C.albicans MTCC 3017 bacterial strains ranged from 2.8 to 28.3 µg/mL. Biofilm inhibition assay showed that the compound 7f exhibited better activity against three bacterial stains with IC50 values from 1.8 to 2.9 µM. All the β-carboline derivatives showed cytotoxic activity, among them compounds 7f and 7h (IC50 values 9.1 and 11.4 µM) were exhibited potential activity. Free radical scavenging activity via DPPH assay revealed that compound 7g acted as good antioxidant molecule than all the tested compounds.

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Pyridine alkaloids with activity in the central nervous system

Abstract: Graphical abstract

Cited by 69 publications

References 180 publications

The Expanding Role of Pyridine and Dihydropyridine Scaffolds in Drug Design

The Expanding Role of Pyridine and Dihydropyridine Scaffolds in Drug Design

Traditional Latvian herbal medicinal plants used to treat parasite infections of small ruminants: A review

Synthesis and characterization of β-carboline fatty alcohol hybrids as potential biological active and antioxidant molecules

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