Pyridine-based lanthanide complexes: towards bimodal agents operating as near infrared luminescent and MRI reporters

Abstract

We report two prototype Ln(3+) complexes that address requirements for both MRI and luminescence imaging and we demonstrate that the presence of two H(2)O molecules bound to the Ln(3+), beneficial for MRI applications of the Gd(3+) analogue, is not a major limitation for the development of NIR luminescent agents.

Novel antennae for the sensitization of near infrared luminescent lanthanide cations

“…11) [64]. The analysis of the behavior of the complexes formed between one equivalent of ligand and one equivalent of lanthanide cation in solution indicate that they are remarkably inert, related to the rigidity of the pyridyl skeleton.…”

Synthesis and Characterization of Ligands and their Gadolinium(III) Complexes

“…Alkylation of dialkyl iminodiacetate by 2,6-bis(bromomethyl)pyridine afforded, after hydrolysis, a H 5 DTPA analog with N 4 -atom incorporated in the pyridine ring [15,16] (Scheme 3.10).…”

“…A similar route led to a number of H 5 DTPA analogs with other heterocyclic moieties [15] or with the incorporated pyridine ring having further functionalities bound to the pyridine moiety, usually in the pyridine C 4 -position [16][17][18][19][20]. Such derivatives were used for further conjugation reactions [21][22][23][24][25].…”

Dinuclear complexes of europium(III) and gadolinium(III) ions with a julolidine–quinoline-based tridentate ligand

“…However, current understanding of similar systems with lanthanide metal ions is underdeveloped with most work completed only in recent decades [1,2]. Yet these systems have been found to exhibit unique properties suited for applications in magnetic, optical, luminescent, and electrochemical fields [3][4][5][6][7][8][9][10].…”