Pyridine derivatives as anti-Alzheimer agents

Veer, Babita; Singh, Ram

doi:10.1016/b978-0-323-91221-1.00017-8

Cited by 1 publication

(2 citation statements)

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“…contributing to improved memory and cognition in AD animal models. 83 Pyridine alkaloids play a vital role in anticholinesterase activity, 84,85 particularly through compounds like trigonelline (TRG), 86 due to their structural similarity to ACh. 87 Both pyridine and TRG contain nitrogen atoms in their ring structures, which interact electrostatically with acetylcholinesterase to prevent ACh breakdown.…”

Section: Dietary Alkaloids As Cholinesterase Inhibitormentioning

confidence: 99%

“…Pyridine analogs, including drugs like donepezil and tacrine, are promising for Alzheimer's treatment, with both being FDA-approved. 88 This has sparked interest in the study of pyridine-containing natural products for their potential anticholinesterase activity, 85,88 highlighting the broader significance of pyridine in various biological aspects.…”

Section: Dietary Alkaloids As Cholinesterase Inhibitormentioning

confidence: 99%

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Bitter yet beneficial: The dual role of dietary alkaloids in managing diabetes and enhancing cognitive function

Alkanad,

Hani,

et al. 2024

BioFactors

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With the rising prevalence of diabetes and its association with cognitive impairment, interest in the use of dietary alkaloids and other natural products has grown significantly. Understanding how these compounds manage diabetic cognitive dysfunction (DCD) is crucial. This comprehensive review explores the etiology of DCD and the effects of alkaloids in foods and dietary supplements that have been investigated as DCD therapies. Data on how dietary alkaloids like berberine, trigonelline, caffeine, capsaicin, 1‐deoxynojirimycin, nuciferine, neferine, aegeline, tetramethylpyrazine, piperine, and others regulate cognition in diabetic disorders were collected from PubMed, Research Gate, Web of Science, Science Direct, and other relevant databases. Dietary alkaloids could improve memory in behavioral models and modulate the mechanisms underlying the cognitive benefits of these compounds, including their effects on glucose metabolism, gut microbiota, vasculopathy, neuroinflammation, and oxidative stress. Evidence suggests that dietary alkaloids hold promise for improving cognition in diabetic patients and could open exciting avenues for future research in diabetes management.

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