Pyridines and Reduced Pyridines of Pharmacological Interest

A New and Flexible Synthesis of 4‐Hydroxypyridines: Rapid Access to Caerulomycins A, E and Functionalized Terpyridines

“…The method allows for a rapid access to 2-aryl pyridines [1] 7 c, 6 d, 7 d, 7 f, 6 g, 7 g and 2,2'-bipyridines [3] 7 h in high yield. Remarkably, this protocol was employed for the preparation of trifluoromethyl-substituted pyridyl nonaflates 7 a and 7 e from the diketones 1 and 2 in good overall yields (41-53 %, entries 1 and 5) using just one column chromatography for purification.…”

“…[1] Substituted pyridine derivatives have also been used as reagents in organic synthesis and for new materials. [2] For example, functionalized 2,2'-bipyridines and 2,2':6',2''-terpyridines have received considerable attention as ligands in transitionmetal catalysis and as building blocks in supramolecular chemistry.…”

Growth Stimulant Agents and Bactericides

“…According to the literature data for the preparation of 4-aminopiperidine the reaction of the reduction of oximes to amines is used or the catalytic process, or lithium aluminum hydride [96][97], and also aminopyridines [98], nicotinic acid and its derivatives [99]. There are established methods for the preparation of 4-aminopiperidine substituted by halogen atom in the 4-halogen piperidine with ammonia and also from piperidin-4-ones by carrying out a reductive amination reaction in the presence of a nickel catalyst [100].…”

Synthesis and antiproliferative activity of various novel indole Mannich bases

“…The cyclization of glutaraldehyde and β-phenylglutaraldehyde, with nitroalkanes to give the nitrodiol which react with two moles of secondary or primary amines afforded the nitro bis-Mannich bases, was reported [15] . 1-alkyl-, 1-aryl-, 1-(alkylamino)-, or 1-amido-substituted and of 1,2,6-trisubstituted piperidines were synthesized by Katritzky and Fan [16] , from the condensation reaction of glutaraldehyde and primary amines or monosubstituted hydrazines with benzotriazole [17,18] . Many N-substituted piperidines and their 2,6-dialkyl derivatives are pharmacologically active and form an essential part of the molecular structure for important drugs [19] .…”