Pyridyl-Isonicotinoyl Hydrazone-Bridged Zn(II) Coordination Framework with Thiophenedicarboxylato Link: Structure, Biological Activity, and Electrical Conductivity

Shit, Manik; Halder, Satyajit; Dey, Arka; Dutta, Basudeb; Chanthapally, Anjana; Jana, Kuladip; Sinha, Chittaranjan

doi:10.1021/acs.inorgchem.3c02593

Cited by 6 publications

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“…Normally, carboxylate-bridging ligands would not conduct electricity due to the presence of insulating C-centers while the presence of metal (even diamagnetic) knots controls the energy difference between valence and conduction bands and make them helpful for electrical communicators and/or semiconductors. − In the past few years, it has been explored that CPs are working as better electrical conductors and storage systems than conventional electrical devices. Some excellent porous conducting polymers (PCPs) of Zn(II), Cd(II), and few other transition metal ions are reported recently. − To the best of our knowledge, Mn(II)-based CPs are still rare in the literature for serving as electrical conductors. It is assumed that d 5 high-spin electronic configuration of Mn(II) having the highest magnetic field may accelerate the electronic properties of the materials.…”

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confidence: 99%

Mn(II) 3D Coordination Framework with Mixed 5-Aminoisophthalato and Pyridyl-isonicotinoyl Hydrazone Bridges: Structure, Electrical Conductivity, Anticancer Activity, and Drug Delivery

Shit,

Halder,

Manna

et al. 2024

ACS Appl. Polym. Mater.

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A 3D coordination polymer of Mn(II), [Mn 2 (aisp) 3 (pcih) 2 (solvent)] n (CP1) (pcih = pyridine-4-carboxaldehyde isonicotinoyl hydrazine and H 2 aisp = 5-aminoisophthalic acid), was constructed by doubly heterobridging ligands and was characterized by single-crystal X-ray diffraction measurements. The noncovalent forces (H-bonding, π•••π interactions) bring robustness and stability (thermal and chemical) to the framework. The optical band gap of CP1 obtained from Tauc's plot (2.98 eV) is comparable with the DFT computation value (HOMO and LUMO energy difference = 2.80 eV) and is crucial for the fabrication of a semiconducting device. A thin-film device ITO/ CP1/Cu was constructed at the measured electrical conductivity of 1.57 × 10 −6 m 2 V −1 s −1 and the series resistance (R s ) of 331 Ω, at a dark phase. Isoniazid, an antibiotic, used to prepare a Schiff base, pcih, and the present compound, CP1, motivated us to examine the anticancer efficiency against as many as four cancer cell lines (HeLa, PC3, MDA-MB 231, A549) and was compared with the NKE (human normal kidney epithelial) cell line. CP1 showed a better impact in inhibiting the proliferation of HeLa cells (IC 50 : 17.58 ± 1.56 μM) than other cancer cells (IC 50 : 21.52 ± 2.44 μM (PC3), 36.41 ± 1.72 μM (MDA-MB 231), 50.29 ± 3.81 μM (A549)). Loading and delivery of drug diclofenac sodium (DMNa) were tested in two different pH = 1.2 (simulated stomach environment) and pH = 7.4 (simulated intestinal environment), which showed ∼8% release at pH 1.2 and ∼87% release at pH 7.4 within 30 h. CP1, a magic material and stable in solution at different pH (1−10), showed multifaceted applications such as being energy saving, anticancer activity, and drug delivery. The design is certainly an important footstep toward the sustainable development goals (SDGs).

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