Pyrimethanil and chlorpyrifos air concentrations and pregnant women’s urinary metabolites in the Infants’ Environmental Health Study (ISA), Costa Rica

Giffin, Andrew; Hoppin, Jane A.; Córdoba, Leonel; Díaz, Karla Solano; Ruepert, Clemens; Castañeda, Jorge Peñaloza; Lindh, Christian; Reich, Brian J.; Joode, Berna van Wendel de

doi:10.1016/j.envint.2022.107328

Cited by 10 publications

(7 citation statements)

References 39 publications

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“…In addition, women who worked in agriculture tended to have higher HCT serum concentrations than women who did not. Similar results were found for mancozeb and chlorpyrifos exposure in the same population [ 32 , 36 , 40 ]. Only a small percentage of the women worked in agriculture during pregnancy (8%), yet of those who did, the vast majority worked on banana plantations [ 35 ].…”

Section: Discussionsupporting

confidence: 86%

“…Among women from the Costa Rican study, residential distance to banana plantations was inversely associated with HCT serum concentrations. Similar findings have been found for urinary metabolite concentrations of the fungicides mancozeb and pyrimethanil, which are also aerially sprayed on bananas [ 32 , 36 , 40 ]. Chlorothalonil has been highly used on bananas in Costa Rica [ 41 ], and aerial spraying of pesticides is common [ 36 ].…”

Section: Discussionsupporting

confidence: 80%

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Detection of the fungicide transformation product 4-hydroxychlorothalonil in serum of pregnant women from Sweden and Costa Rica

Krais

Joode

Liljedahl

et al. 2023

J Expo Sci Environ Epidemiol

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Background 4-hydroxychlorothalonil (HCT, R182281), a transformation product of the fungicide chlorothalonil, was recently identified in human serum and breast milk. There are indications that HCT may be more toxic and environmentally persistent than chlorothalonil. Objective Our aim was to investigate serum concentrations of HCT in pregnant women in Sweden and Costa Rica. Methods We developed a quantitative analytical method for HCT using liquid chromatography tandem mass spectrometry. We measured HCT in 1808 serum samples from pregnant women from the general population in Sweden (1997–2015) and in 632 samples from 393 pregnant women from an agricultural population in Costa Rica (2010–2011). In Swedish samples, we assessed time trends and investigated seasonality. In the Costa Rican samples, we evaluated variability between and within women and explanatory variables of HCT concentrations. Results HCT was detected in all serum samples, and the limit of detection was 0.1 µg/L. The median HCT concentration in the Swedish samples was 4.1 µg/L (interquartile range [IQR] of 2.9 − 5.8 µg/L), and 3.9 times higher in the Costa Rican samples (median: 16.1 µg/L; IQR: 10.6 − 25.0 µg/L). We found clear seasonal variation with higher concentrations in the first half of each year among Swedish women. In the Costa Rican study, women working in agriculture and living near banana plantations had higher HCT concentrations, whilst higher parity and having a partner working in agriculture were associated with decreased HCT, and no clear seasonal pattern was observed. Impact statement For the first time, this study quantifies human exposure to the fungicide chlorothalonil and/or its transformation product 4-hydroxychlorothalonil (HCT, R182281) and finds higher serum concentrations in women from a tropical agricultural setting as compared with women from the general population in Sweden.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 80%

Detection of the fungicide transformation product 4-hydroxychlorothalonil in serum of pregnant women from Sweden and Costa Rica

Krais

Joode

Liljedahl

et al. 2023

J Expo Sci Environ Epidemiol

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“…These agents have protective effects against pathogenic and problematic fungi in plants and agricultural crops. 1 One of the organic fungicides is 4,6-dimethyl- N -phenyl-2-pyrimidinamine, also called pyrimethanil or pyrimethanil, belonging to the anilinopyrimidine category. This fungicide is extensively applied against various pathogenic fungi especially gray mold on agricultural crops.…”

Section: Introductionmentioning

confidence: 99%

An electrochemical sensor for the determination of environmentally hazardous fungicide pyrimethanil in water and fruit samples

Hsu,

Al-Musawi,

Lataef

et al. 2024

Anal. Methods

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“…In order to prevent diseases and invasion of pests to the plants, pesticides and fungicides are widely applied in agriculture, usually sprayed on the surface of fruits and vegetables. Chlorpyrifos and pyrimethanil are widely used insecticides/ fungicides in the world and have been shown to be effective in controlling fruit and vegetable pests and gray mold (Gi n et al, 2022). Chlorpyrifos is a best-selling organophosphate insecticide, while its accumulation in the body may cause a variety of diseases and even affect the neurological development of children (Authority, 2019).…”

Section: Introductionmentioning

confidence: 99%

Rapid detection of residual chlorpyrifos and pyrimethanil on fruit surface by surface- enhanced Raman spectroscopy integrated with deep learning approach

Xuan

Liu

Dong

et al. 2023

Preprint

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Chlorpyrifos and pyrimethanil are widely used insecticides/fungicides in agriculture. The residual pesticides/fungicides remaining in fruits and vegetables may do harm to human health if they are taken without notice by the customers. Therefore, it is important to develop methods and tools for the rapid detection of pesticides/fungicides in fruits and vegetables, which are highly demanded in the current markets. Surface-enhanced Raman spectroscopy (SERS) can achieve trace chemical detection, while it is still a challenge to apply SERS for the detection and identification of mixed pesticides/fungicides. In this work, we tried to combine SERS technique and deep learning spectral analysis for the determination of mixed chlorpyrifos and pyrimethanil on the surface of fruits including apples and strawberries. Especially, the multi-channel convolutional neural networks-gate recurrent unit (MC-CNN-GRU) classification model was used to extract sequence and spatial information in the spectra, so that the accuracy of the optimized classification model could reach 99% even when the mixture ratio of pesticide/fungicide varied considerably. This work therefore demonstrates an effective application of using SERS combined deep learning approach to rapid detection and identification of different mixed pesticides in agricultural products.

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Pyrimethanil and chlorpyrifos air concentrations and pregnant women’s urinary metabolites in the Infants’ Environmental Health Study (ISA), Costa Rica

Cited by 10 publications

References 39 publications

Detection of the fungicide transformation product 4-hydroxychlorothalonil in serum of pregnant women from Sweden and Costa Rica

Detection of the fungicide transformation product 4-hydroxychlorothalonil in serum of pregnant women from Sweden and Costa Rica

An electrochemical sensor for the determination of environmentally hazardous fungicide pyrimethanil in water and fruit samples

Rapid detection of residual chlorpyrifos and pyrimethanil on fruit surface by surface- enhanced Raman spectroscopy integrated with deep learning approach

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