Pyrimidine Biosynthesis in Aerobacter Aerogenes

Abstract

The role of orotic acid in bacterial pyrimidine biosynthesis has been studied by several groups of investigators (Wright et al., 1950a; Weed and Cohen, 1951; Lieberman and Kornberg, 1953). Wright et al. (1950b, 1951) have shown that ureidosuccinic acid will replace partially the orotic acid requirement of Lactobacillus bulgari