Pyrimidines and their Benzo Derivatives

Crystal structure of 2-(4-methoxyphenyl)-2,3-dihydro-1H-perimidine, C18H16N2O

“…Perimidines (peri-naphtho-fused pyrimidine systems) are of interest because they constitute an important class of natural products, which exhibit useful biological activities [2,3]. Moreover, perimidines have wide utility as synthons…”

Facile One-Pot Synthesis of Quinazoline-2,4-dione Derivatives and Application to Naturally Occurring Alkaloids from Zanthoxylum Arborescens

“…Quinazoline-2,4-diones are one of the important heterocycles 1 and have been shown to possess pharmacologically interesting properties such as anti-hypertensive, 2 antidiabetic, 3 and immunosuppressive activities. 4 Among these, synthetic pelanserine (TR2515) (1) 5 is a well established potent anti-hypertensive, having activity comparable to ketanserin, 6 which is an anti-hypertensive agent used clinically.…”

“…4 Among these, synthetic pelanserine (TR2515) (1) 5 is a well established potent anti-hypertensive, having activity comparable to ketanserin, 6 which is an anti-hypertensive agent used clinically. As alkaloids containing the quinazoline-2,4-dione moiety, compounds 2 and 3 were isolated from Zanthoxylum arborescens ( Figure 1).…”

A one-step synthesis of tricyclic pyrimidines

“…They also gained widespread synthetic interest as dyes, 1 flavine model compounds [2][3][4] and due to their various pharmaceutical activities. [5][6][7][8] Many syntheses of such compounds involve metal-catalyzed or multi-step procedures or are restricted to N,N-dialkylated pyrimidines. 1,[6][7][8][9][10][11] Our group previously described the preparation of benzannulated pyrano [2,3-d]pyrimidines from readily available benzophenones and 5-phenylbarbituric acids in a metal-free one-step procedure.…”

“…[5][6][7][8] Many syntheses of such compounds involve metal-catalyzed or multi-step procedures or are restricted to N,N-dialkylated pyrimidines. 1,[6][7][8][9][10][11] Our group previously described the preparation of benzannulated pyrano [2,3-d]pyrimidines from readily available benzophenones and 5-phenylbarbituric acids in a metal-free one-step procedure. 12 Seeking for dyes capable of supramolecular interactions which may be formed from these compounds, we now present further studies on the scopes and limitations as well as the mechanism of this reaction to prepare substituted tricyclic pyrano [2,3-d]pyrimidines 1 and oxazolo [3,2-c]pyrimidines 2 which possess an ADA hydrogen bond pattern at the pyrimidine system.…”