Pyrimidinthiones (Part I): Utility of 2-Thioxopyrimidin-6-(1H)ones as Ring Transformer in the Synthesis of Fused Bi- and Tri-Cyclic Heterocyclic Compounds and Their Potential Biological Activities

Synthesis of Novel Substituted Tetrahydropyrimidine Derivatives and Evaluation of Their Pharmacological and Antimicrobial Activities

“…As stated vide supra and in continuation of our previous work on the synthesis of the biologically active compounds , herein, we investigated 6‐(4‐methoxyphenyl)‐4‐oxo‐2‐thioxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carbonitrile 1 as a key starting material to design‐and synthesize a library of biologically active series of polyfunctionalized pyrimidine‐2‐thione derivatives. Therefore, compound 1 upon alkylation with different reagents such as ethyl iodide in the presence of sodium acetate using (1:1) molar ratio afforded S ‐alkylated product 2 .…”

Behaviour of 4,6-Diaryl-2(1H) pyrimidine-2-thiones Towards Some Electrophiles and Nucleophiles

“…Also, some thiazolopyrimidines were tested for their antiinflammatory activity and exerted a moderate effect (4) . In conjunction with our previous work on the synthesis of pyrimidinethione derivatives for biological evaluations (11)(12)(13)(14)(15)(16) , we report herein on the synthesis of a series involving the pyrimidine-2-thione moiety and screening of the antimicrobial activity of some of the new derivatives.…”

Antioxidant Activity of Novel Fused Heterocyclic Compounds Derived from Tetrahydropyrimidine Derivative

“…The precipitated solid was filtered off, dried and recrystallized from ethanol to give compound 10 as brown crystals, mp 220-222°C, yield 73%. FT-IR (KBr, cm [d][1,3]dioxol-5-yl)-2-(ethylthio)-6-thioxo-1,6dihydropyrimidine-5-carbonitrile (11) A mixture of chloropyrimidine derivative 10 (3.19 g, 0.01 mol), thiourea (0.76 g, 0.01 mol), in ethanol (20 mL) was refluxed for 6 h, cooled. The precipitated solid was filtered, dried and recrystallized from ethanol to afford compound 11 as orange crystals, mp 212-214°C, yield 88%.…”

“…In continuation of our previous work, 11) thiourea is employed as the N-C-N unit and is condensed with arylidene ethyl cyanoacetate to complete the pyrimidine ring namely 6-(benzo [d] [1,3]dioxol-5-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile 1. The present work aimed at utilization of thioxotetrahydropyrimidine 1 as a scaffold for synthesis of different heterocyclic compounds and studies their biological activities as antioxidant agent.…”