Pyrimido[4,5‐f]quinazolines.

Abstract

Fused pyrimidine derivativesFused pyrimidine derivatives R 0515 Pyrimido[4,5-f]quinazolines. -Ongoing research leads to the synthesis of a novel set of the title compounds such as (V). -(TONKIKH, N. N.; STRAKOVS, A.; PETROVA, M. V.; Chem. Heterocycl.

4-Substituted Benzenesulfonamides Incorporating Bi/Tricyclic Moieties Act as Potent and Isoform-Selective Carbonic Anhydrase II/IX Inhibitors

“…The 1,3-bielectrophilic reaction of 7a with nucleophilic reagents, formamidine, acetamidine, or benzamidine hydrochloride in refluxing ethanol for 15−30 h (TLC analysis) led to the pyrimidine derivatives 8a−c, 9 that were then reacted with an excess of DMF-DMA at 100 °C for 1 h to obtain the intermediates 9a−c in very good yields. 10,11 Derivatives 9a−c were then solubilized in ethanol and reacted with a slight excess of commercial 4-hydrazinebenzenesulfonamide hydrochloride, basically according to described procedures. 12−14 The reaction mixture was heated to 80 °C for 20 h and, after cooling, the obtained crude compounds 4a−c were purified by flash chromatography (Scheme 1).…”

ZnO Nanoparticles Solid Phase Acidic Catalyst for One-Pot Synthesis of Octahydroquinazolinone Derivatives

“…Methods employed for their synthesis are variants on the classical one-pot multicomponent Biginelli reaction involving dimedone, aromatic aldehydes and urea 4 . There are very few reports for the synthesis of octahydroquinazolinone derivatives using catalysts 1,[4][5][6][7][8][9] in the extension of the Biginelli reaction, However, many of these procedures are expensive, harmful and are difficult to handle especially on large scale, require longer reaction times, use strongly acidic conditions and give unsatisfactory yields the formation of side products 5 . We have now used ZnO nanoparticles (ZnO NPs) as a solid phase acidic green catalyst which affords excellent yields and in the synthesis of octahydroquinazolinones.…”

Microwave-Assisted One-Pot Synthesis of Octahydroquinazolinone Derivatives Catalyzed by Thiamine Hydrochloride Under Solvent-free Condition

“…However many of these procedures suffer from one or more disadvantages such as harsh reaction conditions, prolonged reaction period, poor yields, use of hazardous and expensive catalysts, strongly acidic conditions and also suffer from the formation of many side products. 8 So the development of clean, high-yielding and environmentally friendly approaches is still desirable and much in demand. Nowadays, an important development in the chemical industry is that many traditional chemical processing techniques are reaching their optimum performance, while consumer's demands stretch and governmental regulations tighten.…”