Pyrogallol enhances therapeutic effect of human umbilical cord mesenchymal stem cells against LPS-mediated inflammation and lung injury via activation of Nrf2/HO-1 signaling

Zhang, Yuehan; Yang, Sushan; Qiu, Zhenhua; Li, Huang; Huang, Linyan; Liang, Yueyun; Liu, Xuanyu; Wang, Maosheng; Zhou, Beixian

doi:10.1016/j.freeradbiomed.2022.08.030

Cited by 13 publications

(9 citation statements)

References 54 publications

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“…Recently, more and more studies indicated that Nrf2 also participated in modulating immune response by targeting different molecular targets. For example, Zhang et al reported that Nrf2 activation could mediate HO-1 signaling to mitigate LPS-induced inflammation and lung injury [ 33 ]. Xiao et al showed that Nrf2 could inhibit nod-like receptor pyrin domain-containing 3 inflammasome-mediated neuroinflammation and pyroptosis after cerebral ischemia-reperfusion injury [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Pterostilbene Attenuates Subarachnoid Hemorrhage-Induced Brain Injury through the SIRT1-Dependent Nrf2 Signaling Pathway

Zhang

Fang

Zhou

et al. 2022

Oxidative Medicine and Cellular Longevity

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Neuroinflammatory injury, oxidative insults, and neuronal apoptosis are major causes of poor outcomes after subarachnoid hemorrhage (SAH). Pterostilbene (PTE), an analog of resveratrol, has been verified as a potent sirtuin 1 (SIRT1) activator. However, the beneficial actions of PTE on SAH-induced brain injury and whether PTE regulates SIRT1 signaling after SAH remain unknown. We first evaluated the dose-response influence of PTE on early brain impairment after SAH. In addition, EX527 was administered to suppress SIRT1 signaling. The results revealed that PTE significantly attenuated microglia activation, oxidative insults, neuronal damage, and early neurological deterioration. Mechanistically, PTE effectively enhanced SIRT1 expression and promoted nuclear factor-erythroid 2-related factor 2 (Nrf2) accumulation in nuclei. Furthermore, EX527 pretreatment distinctly repressed PTE-induced SIRT1 and Nrf2 activation and deteriorated these beneficial outcomes. In all, our study provides the evidence that PTE protects against SAH insults by activating SIRT1-dependent Nrf2 signaling pathway. PTE might be a therapeutic alternative for SAH.

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Section: Discussionmentioning

confidence: 99%

Pterostilbene Attenuates Subarachnoid Hemorrhage-Induced Brain Injury through the SIRT1-Dependent Nrf2 Signaling Pathway

Zhang

Fang

Zhou

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…In AD-MSCs, long-term exposure to a low dose (10 µM) of H 2 O 2 led to increased survival by upregulating 2020). Preconditioning with pyrogallol was also able to enhance UC-MSC therapeutic properties via activation of the Nrf2/HO-1 signaling pathway, leading to a reduction of lung injury, epithelial cell apoptosis, MPO activity, and levels of inflammation-associated mediators (IL-6, IL-8, MCP-1, and TNFα) in experimental LPS-induced ARDS (Zhang et al, 2022).…”

Section: Msc Preconditioning With Pharmacological Agents or Other Sub...mentioning

confidence: 94%

“…Administration of H 2 O 2 -preconditioned UC-MSCs reduced lung remodeling by attenuating expression of α-smooth muscle actin (α-SMA) and TGF-β as well as myeloperoxidase (MPO) activity in experimental bleomycin-induced lung fibrosis ( Mahmoudi et al, 2020 ). Preconditioning with pyrogallol was also able to enhance UC-MSC therapeutic properties via activation of the Nrf2/HO-1 signaling pathway, leading to a reduction of lung injury, epithelial cell apoptosis, MPO activity, and levels of inflammation-associated mediators (IL-6, IL-8, MCP-1, and TNF-α) in experimental LPS-induced ARDS ( Zhang et al, 2022 ).…”

Section: Strategies To Potentiate the Therapeutic Properties Of Mscsmentioning

confidence: 99%

Functional enhancement strategies to potentiate the therapeutic properties of mesenchymal stromal cells for respiratory diseases

Lopes‐Pacheco

Rocco

2023

Front. Pharmacol.

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Respiratory diseases remain a major health concern worldwide because they subject patients to considerable financial and psychosocial burdens and result in a high rate of morbidity and mortality. Although significant progress has been made in understanding the underlying pathologic mechanisms of severe respiratory diseases, most therapies are supportive, aiming to mitigate symptoms and slow down their progressive course but cannot improve lung function or reverse tissue remodeling. Mesenchymal stromal cells (MSCs) are at the forefront of the regenerative medicine field due to their unique biomedical potential in promoting immunomodulation, anti-inflammatory, anti-apoptotic and antimicrobial activities, and tissue repair in various experimental models. However, despite several years of preclinical research on MSCs, therapeutic outcomes have fallen far short in early-stage clinical trials for respiratory diseases. This limited efficacy has been associated with several factors, such as reduced MSC homing, survival, and infusion in the late course of lung disease. Accordingly, genetic engineering and preconditioning methods have emerged as functional enhancement strategies to potentiate the therapeutic actions of MSCs and thus achieve better clinical outcomes. This narrative review describes various strategies that have been investigated in the experimental setting to functionally potentiate the therapeutic properties of MSCs for respiratory diseases. These include changes in culture conditions, exposure of MSCs to inflammatory environments, pharmacological agents or other substances, and genetic manipulation for enhanced and sustained expression of genes of interest. Future directions and challenges in efficiently translating MSC research into clinical practice are discussed.

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“…Traditional Chinese medicine has unique advantages in the treatment of COPD. Clinical practice has confrmed that traditional Chinese medicine nursing has a good efect on relieving symptoms, such as shortness of breath and dyspnea, in patients with chronic respiratory diseases [32,[43][44][45][46][47][48][49]. In this study, patients with COPD were treated with TCM nursing measures, such as emotional nursing, exercise intervention, and acupoint massage, in accordance with the principles of syndrome diferentiation and nursing.…”

Section: Evidence-based Complementary and Alternative Medicinementioning

confidence: 99%

Effects of Ipratropium Bromide Combined with Traditional Chinese Medicine Intervention on the Pulmonary Function and Psychological Status of Patients with Chronic Obstructive Pulmonary Disease

Zhao

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Recently, most scholars have advocated multidisciplinary comprehensive intervention measures for chronic obstructive pulmonary disease (COPD) to improve lung function, relieve symptoms of dyspnea, and improve quality of life. Traditional Chinese medicine (TCM) has rich experience in the treatment of various respiratory system diseases and the rehabilitation of their syndrome differentiation. In this study, total 68 patients with COPD from November 2019 to November 2021 in the hospitals were divided into the control group, ipratropium bromide (IB)-treated group, and IB + TCM-treated group for clinical efficacy observation and to explore the effect of IB combined with TCM on the pulmonary function and psychological status of COPD patients. Patients in the control group were subjected to routine oxygen inhalation, cough and expectorant, and antiviral treatments, while the patients in the IB-treated group were treated with IB and those received in the control group. Patients in the IB + TCM-treated group were treated with IB and TCM intervention. All patients were treated for a month. The results showed that after different interventions, the levels of FEV1, FEV1% pred, FVC, and PEF ( P < 0.05) were significantly increased in all the groups, while levels of TNF-α, IL-6, IL-8, and CRP in serum as well as Hamilton Anxiety Scale and Hamilton Depression scores were significantly decreased. Compared with the control group and IB-treated group, the IB + TCM-treated group presented the greatest changes on all abovementioned indicators and the lowest total incidence of adverse reactions, indicating the biggest improvement of IB + TCM on the symptoms of COPD patients. Therefore, the combination of IB and TCM intervention effectively improved the pulmonary function and psychological status of COPD patients and could be used as an important adjunct for COPD treatment.

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Pyrogallol enhances therapeutic effect of human umbilical cord mesenchymal stem cells against LPS-mediated inflammation and lung injury via activation of Nrf2/HO-1 signaling

Cited by 13 publications

References 54 publications

Pterostilbene Attenuates Subarachnoid Hemorrhage-Induced Brain Injury through the SIRT1-Dependent Nrf2 Signaling Pathway

Pterostilbene Attenuates Subarachnoid Hemorrhage-Induced Brain Injury through the SIRT1-Dependent Nrf2 Signaling Pathway

Functional enhancement strategies to potentiate the therapeutic properties of mesenchymal stromal cells for respiratory diseases

Effects of Ipratropium Bromide Combined with Traditional Chinese Medicine Intervention on the Pulmonary Function and Psychological Status of Patients with Chronic Obstructive Pulmonary Disease

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