Pyrolyzed Ultrasharp Glassy Carbon Microneedles

Zhou, Chaoqun; Aksit, Aykut; Szeto, Betsy; Li, Richard L.; Lalwani, Anil K.; Kysar, Jeffrey W.

doi:10.1002/adem.202270046

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…The authors confirmed the validity of their device both in terms of safety and minimal invasiveness in several animal studies [ 48 , 49 , 50 ]. Additionally, this microneedle is available in metallic [ 53 ] and glassy carbon [ 54 ] versions.…”

Section: Procedures and Techniques For Perilymph Sampling Via A Micro...mentioning

confidence: 99%

Exploring Inner Ear and Brain Connectivity through Perilymph Sampling for Early Detection of Neurological Diseases: A Provocative Proposal

Di Stadio,

Ralli,

Kaski

et al. 2024

Brain Sciences

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Recent evidence shows that it is possible to identify the elements responsible for sensorineural hearing loss, such as pro-inflammatory cytokines and macrophages, by performing perilymph sampling. However, current studies have only focused on the diagnosis of such as otologic conditions. Hearing loss is a feature of certain neuroinflammatory disorders such as multiple sclerosis, and sensorineural hearing loss (SNHL) is widely detected in Alzheimer’s disease. Although the environment of the inner ear is highly regulated, there are several communication pathways between the perilymph of the inner ear and cerebrospinal fluid (CSF). Thus, examination of the perilymph may help understand the mechanism behind the hearing loss observed in certain neuroinflammatory and neurodegenerative diseases. Herein, we review the constituents of CSF and perilymph, the anatomy of the inner ear and its connection with the brain. Then, we discuss the relevance of perilymph sampling in neurology. Currently, perilymph sampling is only performed during surgical procedures, but we hypothesize a simplified and low-invasive technique that could allow sampling in a clinical setting with the same ease as performing an intratympanic injection under direct visual check. The use of this modified technique could allow for perilymph sampling in people with hearing loss and neuroinflammatory/neurodegenerative disorders and clarify the relationship between these conditions; in fact, by measuring the concentration of neuroinflammatory and/or neurodegenerative biomarkers and those typically expressed in the inner ear in aging SNHL, it could be possible to understand if SNHL is caused by aging or neuroinflammation.

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Section: Procedures and Techniques For Perilymph Sampling Via A Micro...mentioning

confidence: 99%

Exploring Inner Ear and Brain Connectivity through Perilymph Sampling for Early Detection of Neurological Diseases: A Provocative Proposal

Di Stadio,

Ralli,

Kaski

et al. 2024

Brain Sciences

Self Cite

View full text Add to dashboard Cite

show abstract

“…To circumvent the current issues apparent in intracochlear administration, our laboratory has developed microneedles that allow for perforation of the RWM with minimal trauma and full reconstitution of the RWM structure within 72 h 19–24 . Several of these studies used an in vivo guinea pig model to assess the physiological consequences of perforation, aspiration, and injection through the RWM with follow‐up hearing studies between 0 and2 h, 48 h, 72 h, and 1 week post‐perforation.…”

Section: Introductionmentioning

confidence: 99%

Physiologic Effects of Microneedle‐Mediated Intracochlear Dexamethasone Injection in the Guinea Pig

et al. 2023

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ObjectivesOral or intratympanic corticosteroids are commonly used to treat sudden sensorineural hearing loss (SSHL), tinnitus, and Meniere disease. Direct intracochlear delivery has been proposed to overcome the variability in bioavailability and efficacy of systemic or middle ear delivery. In this study, we aim to characterize the physiologic consequences of microneedle‐mediated direct intracochlear injection of dexamethasone through the round window membrane (RWM).MethodsIn Hartley guinea pigs (n = 5), a post‐auricular incision followed by bullostomy was made to access the round window membrane. Using 100 μm diameter hollow microneedles, 1.0 μl of 10 mg/ml dexamethasone was injected through the RWM over 1 min. Compound action potential (CAP) and distortion product otoacoustic action emissions (DPOAE) were measured before perforation, at 1 h, and at 5 h following injection. CAP hearing thresholds were measured from 0.5 to 40 kHz, and DPOAE f2 frequencies ranged from 1.0 and 32 kHz. Repeated measures ANOVA followed by pairwise t‐tests were used for statistical analysis.ResultsANOVA identified significant CAP threshold shifts at four frequencies (4, 16, 36, and 40 kHz) and differences in DPOAE at 1 frequency (6 kHz). Paired t‐tests revealed differences between the pre‐perforation and 1 h time point. By 5 h post injection, both CAP hearing thresholds and DPOAE recover and are not significantly different from baseline thresholds.ConclusionDirect intracochlear delivery of dexamethasone via microneedles results in temporary shifts in hearing thresholds that resolve by 5 hours, thus supporting microneedle technology for the treatment of inner ear disorders.Level of EvidenceN/a Laryngoscope, 2023

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Progress in MXene-based materials for microwave absorption

Wang,

Zhao,

et al. 2024

Journal of Materials Science & Technology

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Pyrolyzed Ultrasharp Glassy Carbon Microneedles

Cited by 4 publications

References 24 publications

Exploring Inner Ear and Brain Connectivity through Perilymph Sampling for Early Detection of Neurological Diseases: A Provocative Proposal

Exploring Inner Ear and Brain Connectivity through Perilymph Sampling for Early Detection of Neurological Diseases: A Provocative Proposal

Physiologic Effects of Microneedle‐Mediated Intracochlear Dexamethasone Injection in the Guinea Pig

Progress in MXene-based materials for microwave absorption

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