Pyrone Derivatives from a Mangrove Endophytic Fungus <i>Phomopsis asparagi</i> LSLYZ‐87

Liu, Yayue; Yang, Wencong; Liao, Qingnan; She, Zhigang

doi:10.1002/cbdv.202200491

Cited by 5 publications

(1 citation statement)

References 27 publications

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“…NO determination: all compounds were examined for the effect on the release of NO by BV-2 cell lines using the method described previously [35]. All experiments were carried out in five replicates.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Bioactive Alkaloids from the Mangrove-Derived Fungus Nigrospora oryzae SYSU-MS0024

Chen,

Guo

et al. 2024

Marine Drugs

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Chemical investigation of marine fungus Nigrospora oryzae SYSU-MS0024 cultured on solid-rice medium led to the isolation of three new alkaloids, including a pair of epimers, nigrosporines A (1) and B (2), and a pair of enantiomers, (+)-nigrosporine C (+)-3, and (−)-nigrosporine C (−)-3, together with eight known compounds (4–11). Their structures were elucidated based on extensive mass spectrometry (MS) and 1D/2D nuclear magnetic resonance (NMR) spectroscopic analyses and compared with data in the literature. The absolute configurations of compounds 1–3 were determined by a combination of electronic circular dichroism (ECD) calculations, Mosher’s method, and X-ray single-crystal diffraction technique using Cu Kα radiation. In bioassays, compound 2 exhibited moderate inhibition on NO accumulation induced by lipopolysaccharide (LPS) on BV-2 cells in a dose-dependent manner at 20, 50, and 100 μmol/L and without cytotoxicity in a concentration of 100.0 μmol/L. Moreover, compound 2 also showed moderate acetylcholinesterase (AChE) inhibitory activities with IC50 values of 103.7 μmol/L. Compound 5 exhibited moderate antioxidant activity with EC50 values of 167.0 μmol/L.

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Section: Anti-inflammatory Activitymentioning

confidence: 99%