Pyrophosphate-stabilised amorphous calcium carbonate for bone substitution: toward a doping-dependent cluster-based model

Abstract

Multiscale and multitool advanced characterisation of pyrophosphate-stabilised amorphous calcium carbonates allowed building a cluster-based model paving the way for tunable biomaterials.

Unlocking the potential of amorphous calcium carbonate: A star ascending in the realm of biomedical application

“…Recently, researchers synthesized ACC doped with pyrophosphates as stabilizers through an aqueous solution precipitation method, providing new prospects for designing bioactive bone-replacement materials with variable properties 185 . In mice with cranial damage, the use of polyphosphate-implanted ACC ameliorated the proliferation rate of human bone marrow stem cells and yielded a more effective repair effect than standalone components 179 .…”

“…ICG is employed for further fluorescent detection of the tumor Tissue engineering Pyrophosphate-stabilized ACC. ACC exhibits excellent biocompatibility and the ability to release ions that compose bone minerals 185 Combinations of polyP and ACC microparticles 1. Combinations act as bioseeds for the deposition of bone minerals and as inducers of CAIX gene expression 179 2.…”