2024
DOI: 10.1007/s11030-024-10987-6
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Pyroptosis and chemical classification of pyroptotic agents

Mohammed A. Hara,
Mohamed Ramadan,
Mohammed K. Abdelhameid
et al.

Abstract: Pyroptosis, as a lytic-inflammatory type of programmed cell death, has garnered considerable attention due to its role in cancer chemotherapy and many inflammatory diseases. This review will discuss the biochemical classification of pyroptotic inducers according to their chemical structure, pyroptotic mechanism, and cancer type of these targets. A structure-activity relationship study on pyroptotic inducers is revealed based on the surveyed pyroptotic inducer chemotherapeutics. The shared features in the chemi… Show more

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