2024
DOI: 10.2147/jir.s445573
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Pyroptosis in Osteoarthritis: Molecular Mechanisms and Therapeutic Implications

Yeping Chen,
Daofu Zeng,
Guizheng Wei
et al.

Abstract: Osteoarthritis (OA) is a chronic disease that causes pain and functional impairment by affecting joint tissue. Its global impact is noteworthy, causing significant economic losses and property damage. Despite extensive research, the underlying pathogenesis of OA remain an area of ongoing investigation. It has recently been discovered that the OA progression is significantly influenced by pyroptosis. Pyroptosis is a complex process that involves three pathways culminating in the assembly of Gasdermin-D (GSDMD)-… Show more

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Cited by 7 publications
(1 citation statement)
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“… 5 Gradual wear and degradation of articular cartilage are essential pathological manifestations of OA, diminishing the cushioning ability of the joint, which results in pain and restricted mobility. 6 The treatment of OA includes non-surgical approaches (health management, medication) and surgical interventions. With the advancement in the research of OA’s molecular mechanisms and the maturation of pluripotent stem cell research, new minimally invasive treatment methods have gradually increased.…”
Section: Introductionmentioning
confidence: 99%
“… 5 Gradual wear and degradation of articular cartilage are essential pathological manifestations of OA, diminishing the cushioning ability of the joint, which results in pain and restricted mobility. 6 The treatment of OA includes non-surgical approaches (health management, medication) and surgical interventions. With the advancement in the research of OA’s molecular mechanisms and the maturation of pluripotent stem cell research, new minimally invasive treatment methods have gradually increased.…”
Section: Introductionmentioning
confidence: 99%