2020
DOI: 10.3892/mmr.2020.10984
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Pyrosequencing analysis of IRS1 methylation levels in schizophrenia with tardive dyskinesia

Abstract: Tardive dyskinesia (Td) is a serious side effect of certain antipsychotic medications that are used to treat schizophrenia (ScZ) and other mental illnesses. The methylation status of the insulin receptor substrate 1 (IRS1) gene is reportedly associated with ScZ; however, no study, to the best of the authors' knowledge, has focused on the quantitative dna methylation levels of the IRS1 gene using pyrosequencing in ScZ with or without Td. The present study aimed to quantify dna methylation levels of 4 cpG sites … Show more

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