Pyrrolidine alkaloids and their glycosylated derivatives from the root bark of Dichrostachys cinerea (L) Wight &amp; Arn. (Fabaceae)

Dade, Joël M.E.; Irie-N’Guessan, Genéviève; Komlaga, Gustav; Say, Martial; Timothée, Okpekon Aboua; Boti, Jean Brice; Kablan, Brou Jérôme; Bamba, El Hadji Sawaliho

doi:10.1016/j.phytol.2016.05.002

Cited by 7 publications

(3 citation statements)

References 29 publications

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“…On the basis of a literature survey, compounds of the pyrrolidine type have exhibited various biological activities, such as antioxidative, antifungal, and antibacterial activity; antitumor properties; cytotoxicity; and glycosidase inhibitory; and platelet aggregation inhibitory effects [22,23,24]. It is worth mentioning that pyrrolidines have been found to possess larvicidal activity against Ae.…”

Section: Resultsmentioning

confidence: 99%

Bioactivities of a New Pyrrolidine Alkaloid from the Root Barks of Orixa japonica

et al. 2016

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Abstract:A new pyrrolidine alkaloid named (Z)-3-(4-hydroxybenzylidene)-4-(4-hydroxyphenyl)-1-methylpyrrolidin-2-one was isolated from the ethanol extract of the root barks of Orixa japonica. The structure of the new alkaloid was elucidated on the basis of NMR and MS analysis. The compound exhibited larvicidal activity against the fourth instar larvae of Aedes aegypti (LC 50 = 232.09 µg/mL), Anopheles sinensis (LC 50 = 49.91 µg/mL), and Culex pipiens pallens (LC 50 = 161.10 µg/mL). The new alkaloid also possessed nematicidal activity against Bursaphelenchus xylophilus (LC 50 = 391.50 µg/mL) and Meloidogynein congnita (LC 50 = 134.51 µg/mL). The results indicate that the crude ethanol extract of O. japonica root barks and its isolated pyrrolidine alkaloid have potential for development into natural larvicides and nematicides.

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Section: Resultsmentioning

confidence: 99%

Bioactivities of a New Pyrrolidine Alkaloid from the Root Barks of Orixa japonica

et al. 2016

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“…A previous study isolated alkaloid with pyrrolidine structure from the root bark of Dichrostachys cinerea [16], able to be important in exploration of other pharmacological properties. Indeed, drug molecules, such as some antimalarial ones have pyrrolidine structure.…”

Section: Discussionmentioning

confidence: 99%

Anti-infective Assessment of Dichrostachys cinerea Root Bark, an Ivorian Anti-asthmatic Herbal

Geneviève¹,

Yessé²,

Anderson³

et al. 2018

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Dichrostachys cinerea root bark is used in Ivorian folk to manage asthma attack. As asthma is often accompanied with secondary infections, this study aimed to assess its potential effects of this medicine against microorganisms. An aqueous-alcoholic extract was obtained from Dichrostachys cinerea root bark. The growth of bacteria in the presence of the extract was measured by the method of dilution in microplate. The antiparasitic potent of the extract was determined on cell culture in microplate with determination of the parasitic viability by reading the optical density of wells in optical microscope. The antifungal activity of the extract was measured by the method of dilution in tube. At 200; 100; 50; 25; 12.5; 6.25 and 3.125 mg/mL the extract did not inhibit growth of Staphylococcus aureus, Escherichia coli, Bacillus sp, Pseudomonas aeruginosa and Enterococcus faecalis. IC90 of the plant extract on Trypanosoma brucei brucei, Caenorhabditis elegans and Aspergillus fumigatus was superior to 125 µg/mL and on average 50 µg/mL on Leishmania donovani and Candida albicans. In conclusion, the extract did not exert any significant anti-infective effect towards the studied microorganisms, supposing that Dichrostachys cinerea root bark would be effective only to delete bronchospasm, the main characteristic of asthma attack.

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“…Many of these species are applied as folk medicine and feed in remote areas all over the world [1]. Phytochemical investigation of the Fabaceae family has been widely accomplished by different groups and the presence of flavonoids [1], alkaloids [2], stilbene [3], terpenoids [4], phenolic compounds [5], acylated triterpene glycosides [6] and nitro compounds [7] has been reported. Many of these constituents were found to show antimalarial [8], antitumour [9], anti-inflammatory [10] [11], antihyperlipidemic [12], anti-cancer [13], antibacterial [14], insecticidal [15] and antimicrobial activities [16].…”

Section: Introductionmentioning

confidence: 99%

Profiling of Secondary Metabolites in Aerial Parts of <i>Phanera bracteata</i>

Udomputtimekakul¹,

Pompimon²,

Baison³

et al. 2017

AJPS

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The flavonoid 4',5,7-trihydroxy-6,8-dimethylflavanone (farresol) and 3',4',-4trihydroxy chalcone (isoliquiritigenin) together with triterpenoid (friedelin) were isolated from the aerial parts of P. bracteata. The structure of these compounds was determined on the basis of spectroscopic data including UV, IR, 1-D and 2-D, NMR and mass spectral analysis. This is the first report on the occurrence of these compounds in this plant.

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Pyrrolidine alkaloids and their glycosylated derivatives from the root bark of Dichrostachys cinerea (L) Wight & Arn. (Fabaceae)

Cited by 7 publications

References 29 publications

Bioactivities of a New Pyrrolidine Alkaloid from the Root Barks of Orixa japonica

Bioactivities of a New Pyrrolidine Alkaloid from the Root Barks of Orixa japonica

Anti-infective Assessment of Dichrostachys cinerea Root Bark, an Ivorian Anti-asthmatic Herbal

Profiling of Secondary Metabolites in Aerial Parts of <i>Phanera bracteata</i>

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Pyrrolidine alkaloids and their glycosylated derivatives from the root bark of Dichrostachys cinerea (L) Wight & Arn. (Fabaceae)

Cited by 7 publications

References 29 publications

Bioactivities of a New Pyrrolidine Alkaloid from the Root Barks of Orixa japonica

Bioactivities of a New Pyrrolidine Alkaloid from the Root Barks of Orixa japonica

Anti-infective Assessment of Dichrostachys cinerea Root Bark, an Ivorian Anti-asthmatic Herbal

Profiling of Secondary Metabolites in Aerial Parts of &lt;i&gt;Phanera bracteata&lt;/i&gt;

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Profiling of Secondary Metabolites in Aerial Parts of <i>Phanera bracteata</i>