Pyrrolizidine alkaloids from Liparis nervosa with inhibitory activities against LPS-induced NO production in RAW264.7 macrophages

Huang, Shuai; Zhou, Xian‐Li; Wang, Cuijuan; Wang, You-song; Xiao, Feng; Shan, Lianhai; Guo, Zhiyun; Weng, Jie

doi:10.1016/j.phytochem.2013.03.009

Cited by 51 publications

(29 citation statements)

References 18 publications

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“…The new molecules tested were nervosine I, nervosine II, nervosine III, nervosine IV, nervosine V, nervosine VI, and the previously-described PA were lindelofidine and labumine. Overall, all molecules were effective in this model, with IC 50 values ranging from 2.16 to 38.25 μM [ 38 ].…”

Section: Biological Activity Of Pamentioning

confidence: 99%

Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety

Moreira

Pereira

Valentão

2018

IJMS

208

180

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Pyrrolizidine alkaloids (PA) are widely distributed in plants throughout the world, frequently in species relevant for human consumption. Apart from the toxicity that these molecules can cause in humans and livestock, PA are also known for their wide range of pharmacological properties, which can be exploited in drug discovery programs. In this work we review the current body of knowledge regarding the chemistry, toxicology, pharmacology and food safety of PA.

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Section: Biological Activity Of Pamentioning

confidence: 99%

Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety

Moreira

Pereira

Valentão

2018

IJMS

208

180

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“…C-NMR spectra, in addition to the distortionless enhancement by polarization transfer (DEPT) spectrum, of 1 presented similar properties with lindelofidine. 8) The additional spectra signals corresponding to necic acid moiety properties include δ H 6.91 (1H, dd, J=7.0, 6.5 Hz, H-13), 4 C-NMR and DEPT spectra, which displayed the remaining signals of the two carbonyl carbons at δ C : 175.9 (C-16) and 162.0 (C-11), and a quaternary carbon at δ C : 128.5 (C-12). In the correlation spectroscopy (COSY) spectra, the correlated signals between H-13/H-14 as well as H-17/H-18/H-19 and H-20 were observed.…”

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory Activity of Pyrrolizidine Alkaloids from the Leaves of <i>Madhuca pasquieri</i> (Dubard)

Hoang

Tran

Lee

et al. 2015

CHEMICAL & PHARMACEUTICAL BULLETIN

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A novel pyrrolizidine alkaloids, madhumidine A (1), and two known alkaloids, lindelofidine benzoic acid ester (2) and minalobine B (3) were isolated from the leaves of Madhuca pasquieri (Dubard) H. J. LAM. The chemical structures of these alkaloids were established mainly by NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against lipopolysaccharide-induced nitric oxide production in macrophage RAW264.7 cell. In addition, the cytotoxic activity of all isolated compounds was tested against a panel of cancer cell lines.

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“…The cytotoxicity of the compounds against cultured human tumor cell lines such as MCF–7, HepG2 and H460 cell lines was evaluated by the MTT method as described in our previous paper 14 . Cells treated with DMSO (0.1% v / v ) were used as negative controls, whereas adriamycin (≥98%; Sigma Chemical Co., Ltd., Shanghai, China) was used as the positive control.…”

Section: Methodsmentioning

confidence: 99%

Diterpenoid Alkaloids from Delphinium anthriscifolium var. majus

Shan

Zhang

Gao

et al. 2017

Sci Rep

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Extensive phytochemical investigation on the whole herbs of Delphinium anthriscifolium var. majus led to the identification of fourteen diterpenoid alkaloids, including three new C20–diterpenoid alkaloids (anthriscifolsines A–C, 1–3), six new C19–diterpenoid alkaloids (anthriscifolrines A–F, 4–9), and five know compounds (10–14). Among them, anthriscifolsine A represents a novel C20–diterpenoid alkaloid characterized by a seco C–ring. The structures of the isolated compounds were elucidated by extensive spectroscopic methods, including HR-ESI–MS, X–ray, and 1D and 2D NMR experiments. Bioactivity of compounds 3–6 was evaluated for their cytotoxicity against the MCF–7, HepG2 and H460 cancer cell lines.

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Pyrrolizidine alkaloids from Liparis nervosa with inhibitory activities against LPS-induced NO production in RAW264.7 macrophages

Cited by 51 publications

References 18 publications

Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety

Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety

Anti-inflammatory Activity of Pyrrolizidine Alkaloids from the Leaves of <i>Madhuca pasquieri</i> (Dubard)

Diterpenoid Alkaloids from Delphinium anthriscifolium var. majus

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