Pyrroloquinoline quinone extends <i>Caenorhabditis elegans</i>’ longevity through the insulin/IGF1 signaling pathway-mediated activation of autophagy

Liu, Yang; Qi, Ye; Zhang, Xuguang; Li, Ké; Liang, Xiao; Wang, Meng; Shi, Linran; Luo, Suhui; Zhang, Qiang; Zhang, Xumei

doi:10.1039/d1fo02128a

Cited by 13 publications

(6 citation statements)

References 61 publications

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“…As the DAF-16 target gene, lgg-1 is the orthologous gene of mammalian microtubule-associated protein light chain 3 (MAP-LC3). 44 And LGG-1 is a specific marker protein for the nematode autophagosome. 45 As indicated by the red arrows in Fig.…”

Section: Eufe Promoted Daf-16 Translocation and Expression Activities...mentioning

confidence: 99%

Eucommia ulmoides male flower as a remarkable edible floral resource exerts lifespan/healthspan-promoting effects on Caenorhabditis elegans

et al. 2023

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Section: Eufe Promoted Daf-16 Translocation and Expression Activities...mentioning

confidence: 99%

Eucommia ulmoides male flower as a remarkable edible floral resource exerts lifespan/healthspan-promoting effects on Caenorhabditis elegans

et al. 2023

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“…As lgg-1 is one of the target genes of DAF-16, 28 we investigated whether this transcription factor mediated the above effects of Asp. As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Asperuloside, the bioactive compound in the edible Eucommia ulmoides male flower, delays muscle aging by daf-16 mediated improvement in mitochondrial dysfunction

et al. 2023

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“…We reasoned that PQQ improved mitophagy activity to clear damaged mitochondria at an early stage and enhancing mitochondrial biogenesis and function. Other studies have demonstrated that PQQ promotes autophagy, leading to reduced microglial neuroinflammation ( Zhang Q. et al, 2020 ; Gao et al, 2021 ) and extended longevity in Caenorhabditis elegans ( Yang et al, 2021 ). Therefore, the effects of PQQ on mitophagy activity in aged cells should be studied further.…”

Section: Discussionmentioning

confidence: 99%

Dietary pyrroloquinoline quinone hinders aging progression in male mice and D-galactose-induced cells

Mohamad Ishak,

Kikuchi,

Ikemoto

2024

Front. Aging

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Background: Understanding and promoting healthy aging has become a necessity in the modern world, where life expectancy is rising. The prospective benefits of the antioxidant pyrroloquinoline quinone (PQQ) in healthy aging are promising. However, its role in aging remains unclear. Thus, this study aimed to investigate the effect of PQQ on preventing the progression of aging and to explore its underlying molecular mechanisms.Methods: Naturally aged C57BL/6J male mice were fed a normal diet with or without PQQ (20 mg/kg/day) for 10 weeks. Body composition was measured by bioimpedance at weeks 0 and 8. The integument conditions were evaluated at weeks 0, 4, and 8. Muscle strength and function were examined at week 8. At the ninth week, computed tomography images of the mice were captured, and blood and tissue samples were collected. The levels of inflammatory cytokines in the gastrocnemius muscle were measured, and the muscle fiber cross-sectional area in the soleus muscle was examined. Additionally, a D-galactose (D-gal)-induced cell aging model was used to study the effects of PQQ intervention on cell proliferation, senescence, differentiation, ROS levels, and mitochondrial function in myoblasts (C2C12). Cell proliferation and monolayer permeability of D-gal-induced intestinal epithelial cells (IEC6) were also examined.Results: Aged mice suffered from malnutrition; however, PQQ supplementation ameliorated this effect, possibly by improving metabolic dysfunction and small intestinal performance. PQQ prevented rapid loss of body fat and body fluid accumulation, attenuated muscle atrophy and weakening, reduced chronic inflammation in skeletal muscles, and improved skin and coating conditions in aged mice. Furthermore, PQQ intervention in D-gal-treated C2C12 cells improved mitochondrial function, reduced cellular reactive oxygen species (ROS) levels and senescence, and enhanced cell differentiation, consequently preventing age-related muscle atrophy. In addition, PQQ increased cell proliferation in D-gal-treated IEC6 cells and consequently improved intestinal barrier function.Conclusion: PQQ could hinder the aging process and particularly attenuate muscle atrophy, and muscle weakness by improving mitochondrial function, leading to reduced age-related oxidative stress and inflammation in muscles. PQQ may also ameliorate malnutrition caused by intestinal barrier dysfunction by enhancing IEC proliferation. This study provides evidence for the role of PQQ in aging and suggests that PQQ may be a potential nutritional supplementation that can be included in healthy aging strategies.

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Pyrroloquinoline quinone extends Caenorhabditis elegans’ longevity through the insulin/IGF1 signaling pathway-mediated activation of autophagy

Abstract: Activation of autophagy involves PQQ-induced longevity effects.

Cited by 13 publications

References 61 publications

Eucommia ulmoides male flower as a remarkable edible floral resource exerts lifespan/healthspan-promoting effects on Caenorhabditis elegans

Eucommia ulmoides male flower as a remarkable edible floral resource exerts lifespan/healthspan-promoting effects on Caenorhabditis elegans

Asperuloside, the bioactive compound in the edible Eucommia ulmoides male flower, delays muscle aging by daf-16 mediated improvement in mitochondrial dysfunction

Dietary pyrroloquinoline quinone hinders aging progression in male mice and D-galactose-induced cells

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