Pyrroloquinoline quinone nutritional status alters lysine metabolism and modulates mitochondrial DNA content in the mouse and rat

Bauerly, Kathryn; Storms, David H.; Harris, Calliandra; Hajizadeh, Shahin; Sun, Mingchi; Cheung, C.; Satre, Michael; Fascetti, Andrea J.; Tchaparian, Eskouhie; Rucker, Robert B.

doi:10.1016/j.bbagen.2006.07.009

Cited by 42 publications

(45 citation statements)

References 40 publications

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“…The ADG and feed efficiency in 0.20 mg/kg PQQ.Na 2 group was comparable to PC (antibiotic growth promoter) group, which indicated that PQQ.Na 2 had potential as a growth promoter in broiler chicks. The improved feed efficiency by dietary PQQ.Na 2 was probably associated with improved metabolism of essential amino acid lysine (Bauerly et al, 2006) or the modulation of mitochondrial function . It is said that mitochondrial function is highly correlated with feed efficiency in broilers (Bottje et al, 2006).…”

Section: Discussionmentioning

confidence: 97%

Effects of dietary pyrroloquinoline quinone disodium on growth performance, carcass yield and antioxidant status of broiler chicks

Samuel

Zhang

Wang

et al. 2015

Animal

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Pyrroloquinoline quinone (PQQ), a putative essential nutrient and redox modulator in microorganisms, cell and animal models, has been recognized as a growth promoter in rodents. Growth performance, carcass yield and antioxidant status were evaluated on broiler chickens fed different levels of PQQ disodium (PQQ.Na 2 ). A total of 784 day-old male Arbor Acres (AA) broilers were randomly allotted into seven dietary groups: negative control group (NC) fed a basal diet without virginiamycin (VIR) or PQQ.Na 2 ; a positive control group (PC) fed a diet with 15 mg of VIR/kg diet; and PQQ.Na 2 groups fed with 0.05, 0.10, 0.20, 0.40 or 0.80 mg PQQ.Na 2 /kg diet. Each treatment contained eight replicates with 14 birds each. The feeding trial lasted for 6 weeks. The results showed that chicks fed 0.2 mg PQQ.Na 2 /kg diet significantly improved growth performance comparable to those in PC group, and the feed efficiency enhancement effects of dietary PQQ.Na 2 was more apparent in grower phase. Dietary addition of PQQ.Na 2 had the potential to stimulate immune organs development, and low level dietary addition (<0.1 mg/kg) increased plasma lysozyme level. Broilers fed 0.2 mg PQQ.Na 2 /kg diet gained more carcasses at day 42, and had lower lipid peroxide malondialdehyde content and higher total antioxidant power in plasma. The results indicated that dietary PQQ.Na 2 (0.2 mg/kg diet) had the potential to act as a growth promoter comparable to antibiotic in broiler chicks.

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Section: Discussionmentioning

confidence: 97%

Effects of dietary pyrroloquinoline quinone disodium on growth performance, carcass yield and antioxidant status of broiler chicks

Samuel

Zhang

Wang

et al. 2015

Animal

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“…PQQ stimulates mitochondriogenesis with the addition of only milligram quantities of PQQ per kg of diet, or micromolar concentrations, in vivo. For example, PQQ deprivation depresses mitochondrial function, which is reversed when as little as 200 -300 g of PQQ/kg of diet are added (1,10). PQQ also remains detectable in tissues when there is no or little dietary exposure (11), which has not been observed for other dietary polyphenolic compounds known to promote mitochondriogenesis.…”

mentioning

confidence: 81%

“…Twenty-four hours later cells were incubated in PQQ supplemented media for 48 h, and cell protein was isolated as described above, except that cells were homogenized with 12 strokes of a Dounce homogenizer, and SDS was omitted. Cytochrome c oxidase activity was assessed as described previously (10).…”

Section: Pgc-1␣ Promotermentioning

confidence: 99%

Pyrroloquinoline Quinone Stimulates Mitochondrial Biogenesis through cAMP Response Element-binding Protein Phosphorylation and Increased PGC-1α Expression

Chowanadisai

Bauerly

Tchaparian

et al. 2010

Journal of Biological Chemistry

205

172

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Bioactive compounds reported to stimulate mitochondrial biogenesis are linked to many health benefits such increased longevity, improved energy utilization, and protection from reactive oxygen species. Previously studies have shown that mice and rats fed diets lacking in pyrroloquinoline quinone (PQQ) have reduced mitochondrial content. Therefore, we hypothesized that PQQ can induce mitochondrial biogenesis in mouse hepatocytes. Exposure of mouse Hepa1-6 cells to 10 -30 M PQQ for 24 -48 h resulted in increased citrate synthase and cytochrome c oxidase activity, Mitotracker staining, mitochondrial DNA content, and cellular oxygen respiration. The induction of this process occurred through the activation of cAMP response element-binding protein (CREB) and peroxisome proliferator-activated receptor-␥ coactivator-1␣ (PGC-1␣), a pathway known to regulate mitochondrial biogenesis. PQQ exposure stimulated phosphorylation of CREB at serine 133, activated the promoter of PGC-1␣, and increased PGC-1␣ mRNA and protein expression. PQQ did not stimulate mitochondrial biogenesis after small interfering RNA-mediated reduction in either PGC-1␣ or CREB expression. Consistent with activation of the PGC-1␣ pathway, PQQ increased nuclear respiratory factor activation (NRF-1 and NRF-2) and Tfam, TFB1M, and TFB2M mRNA expression. Moreover, PQQ protected cells from mitochondrial inhibition by rotenone, 3-nitropropionic acid, antimycin A, and sodium azide. The ability of PQQ to stimulate mitochondrial biogenesis accounts in part for action of this compound and suggests that PQQ may be beneficial in diseases associated with mitochondrial dysfunction.Bioactive compounds, such as pyrroloquinoline quinone (PQQ), 2 resveratrol, genistein, hydroxy-tyrosol, and quercetin have been reported to improve mitochondrial respiratory control or stimulate mitochondrial biogenesis (1-5), which is potentially important to a number of health-related issues ranging from increased longevity, improved energy utilization, and protection from reactive oxygen species (6 -8). Furthermore, mitochondrial DNA depletion and mutations are associated with cardiomyopathy, lactic acidosis, developmental delay, failure to thrive, and impaired neurological function (9). The response to most biofactors is observed after pharmacological intervention or dietary supplementation, although often neargram amounts per kg of diet, or millimolar quantities, are needed for such responses in vivo. PQQ stimulates mitochondriogenesis with the addition of only milligram quantities of PQQ per kg of diet, or micromolar concentrations, in vivo. For example, PQQ deprivation depresses mitochondrial function, which is reversed when as little as 200 -300 g of PQQ/kg of diet are added (1, 10). PQQ also remains detectable in tissues when there is no or little dietary exposure (11), which has not been observed for other dietary polyphenolic compounds known to promote mitochondriogenesis.Recently, PQQ produced by rhizobacterium has been identified as an important plant growth factor (12) and is a...

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“…This substance, initially identified as a coenzyme necessary for certain oxidation-reduction reactions and cell signaling pathways, has recently become of interest as a potentially critical coenzyme in mammals. [14][15][16][17][18][25][26][27][28][29] The importance of PQQ in mammalian health has been reported based on its omission from chemically defined diets, resulting in a wide range of systemic responses, including growth impairment, compromised immune responsiveness, and abnormal reproductive performance in mouse and rat experimental models. 11-13-13,17,18 In the immune system, PQQ deficiency is associated with a reduction in interleukin (IL)-2 level and decreased Tand B-cell sensitivity to mitogens 12 .…”

Section: Discussionmentioning

confidence: 99%

“…10,11 Previous nutrition studies have indicated a metabolic and nutrition role of PQQ in mammals. [11][12][13][14][15][16][17][18] When mice were…”

mentioning

confidence: 99%

Influence of Adding Pyrroloquinoline Quinone to Parenteral Nutrition on Gut‐Associated Lymphoid Tissue

Omata

Fukatsu

Murakoshi

et al. 2011

J Parenter Enteral Nutr

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Background: Experimental intravenous (IV) parenteral nutrition (PN) diminishes gut‐associated lymphoid tissue (GALT) cell number and function. PN solution cannot maintain GALT at the same level as a normal diet, even when delivered intragastrically (IG). Previous studies demonstrated pyrroloquinoline quinone (PQQ)–deficient mice to be less immunologically responsive. Because standard (STD) PN solution lacks PQQ, PQQ supplementation may prevent PN‐induced GALT changes. This study was designed to determine the influence of adding PQQ to PN on GALT. Methods: In experiment 1, mice (n = 32) were randomized to chow, IV‐STD‐PN, and IV‐PQQ‐PN groups. The chow group was fed chow with the same caloric content as PN. The IV‐STD‐PN group received STD‐PN solution, whereas the IV‐PQQ‐PN group was given PQQ (3 mcg/d)–enriched PN by the IV route. After 5 days of feeding, lymphocytes were isolated from the Peyer's patch (PPs), intraepithelial space (IE), and lamina propria (LP) of the small intestine. GALT lymphocyte number and phenotype (αβTCR+, γδTCR+, CD4+, CD8+, B220+ cells) and intestinal immunoglobulin A (IgA) level were determined. In experiment 2, mice (n = 28) were randomized to IG‐STD‐PN or IG‐PQQ‐PN group. After IG nutrition supports, GALT mass and function were determined as in experiment 1. Results: The IV‐PQQ‐PN group showed increased PP lymphocyte number and PP CD8+ cell number compared with the IV‐STD PN group. The IG‐PQQ‐PN group had significantly greater PP lymphocyte number and PP CD4+ cell numbers than the IG‐STD‐PN group. Neither IV nor IG PQQ treatment raised IgA level. Conclusions: PQQ added to PN partly restores GALT mass, although its effects on GALT function remain unclear.

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Pyrroloquinoline quinone nutritional status alters lysine metabolism and modulates mitochondrial DNA content in the mouse and rat

Cited by 42 publications

References 40 publications

Effects of dietary pyrroloquinoline quinone disodium on growth performance, carcass yield and antioxidant status of broiler chicks

Effects of dietary pyrroloquinoline quinone disodium on growth performance, carcass yield and antioxidant status of broiler chicks

Pyrroloquinoline Quinone Stimulates Mitochondrial Biogenesis through cAMP Response Element-binding Protein Phosphorylation and Increased PGC-1α Expression

Influence of Adding Pyrroloquinoline Quinone to Parenteral Nutrition on Gut‐Associated Lymphoid Tissue

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